Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area

被引:0
|
作者
V. G. Motin
机构
[1] Russian Academy of Medical Sciences,P. K. Anokhin institute of Nornal Physiology
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout).
引用
收藏
页码:844 / 847
页数:3
相关论文
共 50 条
  • [21] The model of glutamate-induced intracellular Ca2+ oscillation and intercellular Ca2+ wave in brain astrocytes
    Goto, I
    Kinoshita, S
    Natsume, K
    NEUROCOMPUTING, 2004, 58 : 461 - 467
  • [22] NMDA AND QUISQUALATE INDUCED NEURONAL DEPOLARIZATIONS AND CHANGES IN EXTRACELLULAR NA+, MG2+ AND CA2+ CONCENTRATIONS IN AREA CA1 OF INVITRO HIPPOCAMPAL SLICES
    HEINEMANN, U
    LAMBERT, JDC
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1984, 402 : R30 - R30
  • [23] The model of glutamate-induced intracellular Ca2+ oscillation and intercellular Ca2+ wave in brain astrocytes
    Goto, I
    Kinoshita, S
    Natsume, K
    COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004, 2004, : 461 - 467
  • [24] Regulation of postsynaptic Ca2+ influx in hippocampal CA1 pyramidal neurons via extracellular carbonic anhydrase
    Fedirko, Nataliya
    Avshalumov, Marat
    Rice, Margaret E.
    Chesler, Mitchell
    JOURNAL OF NEUROSCIENCE, 2007, 27 (05): : 1167 - 1175
  • [25] Effects of extracellular pH on voltage-gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons
    Tombaugh, GC
    Somjen, GG
    JOURNAL OF PHYSIOLOGY-LONDON, 1996, 493 (03): : 719 - 732
  • [26] External alkalosis enhances the glutamate-induced destabilization of Ca2+ homeostasis in cultured cerebellar granule cells
    Vergun, OV
    Storozhevykh, TP
    Vinskaya, NP
    Fajuk, DA
    Pinelis, VG
    Khodorov, BI
    BIOLOGICHESKIE MEMBRANY, 1996, 13 (03): : 236 - 243
  • [27] PHILANTHOTOXIN INHIBITS CA2+ CURRENTS IN RAT HIPPOCAMPAL CA1 NEURONS
    KARST, H
    JOELS, M
    WADMAN, WJ
    PIEK, T
    EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 1994, 270 (04): : 357 - 360
  • [28] Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+
    Haiyu Liu
    Sai Zhang
    Liang Zhang
    BMC Neuroscience, 22
  • [29] Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+
    Liu, Haiyu
    Zhang, Sai
    Zhang, Liang
    BMC NEUROSCIENCE, 2021, 22 (01)
  • [30] Tolbutamide blocks Ca2+- and voltage-dependent K+ currents of hippocampal Ca1 neurons
    Erdemli, G
    Krnjevic, K
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 304 (1-3) : 37 - 47