Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

被引：9

作者：

Feng Y. ^{[1
]}

Zhao H. ^{[1
]}

Zhang L. ^{[1
]}

Guo J. ^{[1
]}

机构：

[1] School of Chemical Engineering and Technology, Tianjin University

来源：

Frontiers of Chemical Engineering in China | 2010年 / 4卷 / 3期

关键词：

Anticoagulative; Biomaterials; Biomimetic; Hemocompatibility; Phosphorylcholine; Photochemical immobilization; Photograft polymerization; Photolinker; Surface modification;

D O I：

10.1007/s11705-010-0005-z

中图分类号：

学科分类号：

摘要：

Thrombus formation and blood coagulation are serious problems associated with blood contacting products, such as catheters, vascular grafts, artificial hearts, and heart valves. Recent progresses and strategies to improve the hemocompatibility of biomaterials by surface modification using photochemical immobilization and photograft polymerization are reviewed in this paper. Three approaches to modify biomaterial surfaces for improving the hemocompatibility, i. e., bioinert surfaces, immobilization of anticoagulative substances and biomimetic surfaces, are introduced. The biomimetic amphiphilic phosphorylcholine and Arg-Gly-Asp (RGD) sequence are the most effective and most often employed biomolecules and peptide sequence for improving hemocompatibility of material surfaces. The RGD sequence can enhance adhesion and growth of endothelial cells (ECs) on material surfaces and increase the retention of ECs under flow shear stress conditions. This surface modification is a promising strategy for biomaterials especially for cardiovascular grafts and functional tissue engineered blood vessels. © 2010 Higher Education Press and Springer-Verlag Berlin Heidelberg.

引用

页码：372 / 381

页数：9

共 71 条

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