MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

被引：0
|
作者：
Salomé LeibundGut-Landmann
Jean-Marc Waldburger
Caetano Reis e Sousa
Hans Acha-Orbea
Walter Reith
机构：
[1] University of Geneva Medical School,Department of Pathology and Immunology
[2] Immunobiology Laboratory,Department of Biochemistry
[3] Cancer Research UK,Division of Rheumatology
[4] London Research Institute,undefined
[5] Faculty of Biology and Medicine,undefined
[6] University of Lausanne,undefined
[7] University Hospital,undefined
来源：
Nature Immunology | 2004年 / 5卷
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摘要：
Major histocompatibility complex (MHC) class II–restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other DC subsets with respect to expression of CIITA, the 'master regulator' of MHC class II genes. The gene encoding CIITA is controlled by three cell type–specific promoters: pI, pIII and pIV. With gene targeting in mice, we demonstrate that pDCs rely strictly on the B cell promoter pIII, whereas macrophages and all other DCs depend on pI. The molecular mechanisms driving MHC class II expression in pDCs are thus akin to those operating in lymphoid rather than myeloid cells.
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页码：899 / 908
页数：9
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