Molecular bases of osteoporosis in HIV: The role of the virus and antiretroviral therapy

被引：3
作者：
D. Gibellini
M. Borderi
E. Vanino
A. Clò
S. Morini
L. Calza
M. C. Re
Pl. Viale
机构：
[1] Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, Bologna
[2] Department of Internal Medicine, Aging and Nephrology, Infectious Diseases Section, University of Bologna, Bologna
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2012年 / 10卷 / 4期
关键词：
Antiretrovirals; Bone; HIV; Osteopenia/osteoporosis; Virus;
D O I：
10.1007/s12018-012-9133-y
中图分类号：
学科分类号：
摘要：
In addition to immune system, HIV infection can determine the onset of functional dysfunctions of several organs and tissues such as central nervous system, cardiovascular system, kidney, and bone. It is noteworthy that HIV-infected individuals show an increased risk of bone mass loss with subsequent osteopenia and osteoporosis development. Interestingly, antiretroviral therapy is not able to tackle the bone derangement but, on the contrary, it can induce a progressive bone mass loss, especially when specific antiretroviral drugs are used. In this report, we summarized the HIV and antiretroviral-related mechanisms involved in the osteopenia and osteoporosis induction. © 2012 Springer Science+Business Media, LLC.
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页码：236 / 245
页数：9
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  • [1] Lohse N., Hansen A.-B.E., Pedersen G., Kronborg G., Gerstoft J., Sorensen H.T., Vaeth M., Obel N., Survival of persons with and without HIV infection in Denmark, 1995-2005, Annals of Internal Medicine, 146, 2, pp. 87-95, (2007)
  • [2] Levy J.A., HIV pathogenesis: 25 years of progress and persistent challenges, AIDS, 23, pp. 147-160, (2009)
  • [3] Borderi M., Gibellini D., Vescini F., Et al., Metabolic bone disease in HIV infection, AIDS, 23, pp. 1297-1310, (2009)
  • [4] Womack J.A., Goulet J.L., Gibert C., Et al., Increased risk of fragility fractures among HIV infected compared to uninfected male veterans, PLoS ONE, 6, (2011)
  • [5] Dempster D.W., Anatomy and functions of the adult skeleton, primer on the metabolic bone diseases and disorders of mineral metabolism, The American Society for Bone and Mineral Research, pp. 7-11, (2006)
  • [6] Matsuo K., Irie N., Osteoclast-osteoblast communication, Arch Biochem Bioph, 473, pp. 201-209, (2008)
  • [7] Sims N.A., Gooi J.H., Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption, Semin Cell Dev Biol, 19, pp. 444-451, (2008)
  • [8] Takayanagi H., Osteoimmunology and the effects of the immune system on bone, Nat Rev Rheumatol, 5, pp. 667-676, (2009)
  • [9] Agrawal M., Arora S., Li J., Rahmani R., Sun L., Steinlauf A.F., Mechanick J.I., Zaidi M., Bone, inflammation, and inflammatory bowel disease, Curr Osteoporos Rep, 9, pp. 251-257, (2011)
  • [10] Baker-Lepain J.C., Nakamura M.C., Lane N.E., Effects of inflammation on bone: An update, Curr Opin Rheumatol, 23, pp. 389-395, (2011)
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