Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men

被引：12

作者：

Kumagai H. ^{[1
]}

Miyaki A. ^{[2
]}

Higashino R. ^{[1
]}

Akazawa N. ^{[2
]}

Choi Y. ^{[2
]}

Ra S.-G. ^{[1
]}

Eto M. ^{[2
]}

Tanaka K. ^{[2
]}

Ajisaka R. ^{[2
]}

Maeda S. ^{[2
]}

机构：

[1] Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577

[2] Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577

来源：

Artery Research | 2014年 / 8卷 / 3期

基金：

日本学术振兴会;

关键词：

Arterial stiffness; Lifestyle modification; Obesity; Testosterone;

D O I：

10.1016/j.artres.2014.04.003

中图分类号：

学科分类号：

摘要：

Background: Arterial stiffness-a risk factor for cardiovascular diseases-is more frequently observed in obese men. Moreover, the male sex hormone testosterone has an anti-atherogenic effect. Serum testosterone levels are found to be lower in obese men than in age-matched normal-weight men. However, the effect of lifestyle modification on testosterone in obese men has not been elucidated. Here, we examined the effect of lifestyle modifications on serum testosterone levels and arterial stiffness in overweight and obese men. Methods: Eleven overweight and obese men (mean age: 53 ± 3 years) completed a 12-week lifestyle modification program. Before and after the program, we measured the mean blood pressure (MBP), carotid-femoral pulse wave velocity (cfPWV; as an index of arterial stiffness), and the serum total testosterone levels in all participants. Results: We observed a significant weight loss after the 12-week lifestyle modification program. After the program, MBP and cfPWV significantly decreased and serum testosterone levels significantly increased. Moreover, we observed a negative relationship between the change in serum testosterone levels and that in cfPWV, although this relationship was affected by change in MBP. Conclusions: Lifestyle modification increased the serum testosterone levels in overweight and obese men. The increase in serum testosterone levels was associated with a corresponding reduction in MBP and arterial stiffness. These results suggest that an increase in the testosterone levels may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness. However, the association may not be direct, but may be mediated by a change in the MBP. © 2014 Association for Research into Arterial Structure and Physiology.

引用

页码：80 / 87

页数：7

共 38 条

[1]

Hubert H.B., Feinleib M., McNamara P.M., Castelli W.P., Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study, Circulation, 67, pp. 968-977, (1983)

[2]

Zhang C., Rexrode K.M., van Dam R.M., Li T.Y., Hu F.B., Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women, Circulation, 117, pp. 1658-1667, (2008)

[3]

Hodes R.J., Lakatta E.G., McNeil C.T., Another modifiable risk factor for cardiovascular disease? Some evidence points to arterial stiffness, J Am Geriatr Soc, 43, pp. 581-582, (1995)

[4]

Safar M.E., London G.M., Therapeutic studies and arterial stiffness in hypertension: recommendations of the European Society of Hypertension. The Clinical Committee of Arterial Structure and Function. Working Group on Vascular Structure and Function of the European Society of Hypertension, J Hypertens, 18, pp. 1527-1535, (2000)

[5]

Danias P.G., Tritos N.A., Stuber M., Botnar R.M., Kissinger K.V., Manning W.J., Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults, Am J Cardiol, 91, pp. 195-199, (2003)

[6]

Wildman R.P., Mackey R.H., Bostom A., Thompson T., Sutton-Tyrrell K., Measures of obesity are associated with vascular stiffness in young and older adults, Hypertension, 42, pp. 468-473, (2003)

[7]

Miyaki A., Maeda S., Yoshizawa M., Misono M., Saito Y., Sasai H., Et al., Effect of weight reduction with dietary intervention on arterial distensibility and endothelial function in obese men, Angiology, 60, pp. 351-357, (2009)

[8]

Miyaki A., Maeda S., Yoshizawa M., Misono M., Saito Y., Sasai H., Et al., Effect of habitual aerobic exercise on body weight and arterial function in overweight and obese men, Am J Cardiol, 104, pp. 823-828, (2009)

[9]

Muller M., den Tonkelaar I., Thijssen J.H., Grobbee D.E., van der Schouw Y.T., Endogenous sex hormones in men aged 40-80 years, Eur J Endocrinol, 149, pp. 583-589, (2003)

[10]

Foresta C., Di Mambro A., Pagano C., Garolla A., Vettor R., Ferlin A., Insulin-like factor 3 as a marker of testicular function in obese men, Clin Endocrinol (Oxf), 71, pp. 722-726, (2009)

← 1 2 3 4 →