Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model

被引:0
|
作者
Adrian Ciurea
Lukas Hunziker
Rolf M. Zinkernagel
Hans Hengartner
机构
[1] Institute for Experimental Immunology,
[2] University Hospital,undefined
[3] Schmelzbergstrasse 12,undefined
[4] 8091 Zürich,undefined
[5] Switzerland,undefined
来源
Immunogenetics | 2001年 / 53卷
关键词
Lymphocytic choriomeningitis virus Virus persistence Neutralizing antibody Virus escape Cytotoxic T-lymphocyte deficiency;
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摘要
In addition to CD8+ cytotoxic T lymphocyte (CTL) responses, neutralizing antibodies contribute substantially to the long-term immune control of noncytopathic viruses, as demonstrated during infection with the lymphocytic choriomeningitis virus (LCMV). The high virus load during the initial phase of an infection and the ability of this RNA virus to spontaneously acquire mutations are important prerequisites for escaping an ongoing immune response. In this context, LCMV escape from the humoral response by single point mutations in neutralizing envelope protein determinants may occur, particularly during conditions of CTL deficiency, leading to virus persistence.
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页码:185 / 189
页数:4
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