WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment

被引：0
|
作者：
Thinh P. Phan
Christopher H. Crane
Nora A. Janjan
Eduord Vrdoljak
Luka Milas
Kathy A. Mason
机构：
[1] The University of Texas M.D. Anderson Cancer Center,Department of Experimental Radiation Oncology
[2] The University of Texas M.D. Anderson Cancer Center,Department of Radiation Oncology
[3] University of Split School of Medicine,Center of Oncology and Radiotherapy
[4] Clinic Hospital,undefined
来源：
International Journal of Pancreatology | 2001年 / 29卷
关键词：
Gemcitabine; WR-2721 (amifostine); radiation damage; radioprotector; pancreatic cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background. The nucleoside analog gemcitabine is a potent radiosensitizer of both tumor and normal mucosa, so severe toxic reactions have resulted from its combination with radiation in some clinical treatment schedules for pancreatic cancer. WR-2721 (amifostine) has been shown to reduce normal tissue toxicity produced from both radiation treatment and some chemotherapeutics. The aim of this study was to determine if WR-2721 can protect the gastrointestinal mucosa from injury by concurrent gemcitabine and radiation treatment.
引用
收藏
页码：19 / 23
页数：4
相关论文
共 50 条
  • [41] Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation
    Molkentine, Jessica M.
    Fujimoto, Tara N.
    Horvath, Thomas D.
    Grossberg, Aaron J.
    Garcia, Carolina J. Garcia
    Deorukhkar, Amit
    Bonilla, Marimar de la Cruz
    Lin, Daniel
    Samuel, Errol L. G.
    Chan, Wai Kin
    Lorenzi, Philip L.
    Piwnica-Worms, Helen
    Dantzer, Robert
    Tour, James M.
    Mason, Kathryn A.
    Taniguchi, Cullen M.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [42] COMPARISON OF MITHRAMYCIN, CISPLATINUM, AND WR-2721 IN THE TREATMENT OF HYPERCALCEMIA OF MALIGNANCY (HM)
    SHEVRIN, DH
    BOARD, PS
    SCHOR, JA
    MULLANE, MR
    LAD, TE
    KUKREJA, SC
    CLINICAL RESEARCH, 1986, 34 (04): : A933 - A933
  • [43] PROTECTION AGAINST COLONIC RADIATION-INJURY IN RATS BY INTRACOLONIC WR-2721
    FRANCE, HG
    MANSBACH, CM
    JIRTLE, RL
    GASTROENTEROLOGY, 1986, 90 (05) : 1420 - 1420
  • [44] NORMAL TISSUE PROTECTION AGAINST LATE RADIATION-INJURY BY WR-2721
    UTLEY, JF
    QUINN, CM
    WHITE, FC
    SEAVER, NA
    BLOOR, CM
    RADIATION RESEARCH, 1980, 83 (02) : 451 - 451
  • [45] Protective effect of WR-2721 on the combined radiation-burn injury in mice
    Shi, Yan
    Guo, Zhaohua
    Wang, Zhiwen
    Zhou, Yanhong
    Luo, Chengji
    Fushe Yanjiu yu Fushe Gongyi Xuebao/Journal of Radiation Research and Radiation Processing, 16 (04): : 225 - 230
  • [46] INFLUENCE OF WR-2721 ON RADIATION RESPONSE OF CANINE SOFT-TISSUE SARCOMAS
    MCCHESNEY, SL
    GILLETTE, EL
    DEWHIRST, MW
    WITHROW, SJ
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1986, 12 (11): : 1957 - 1963
  • [47] EFFECTS OF ETHIOFOS (WR-2721) AND RADIATION ON MONKEY VISUAL-DISCRIMINATION PERFORMANCE
    BOGO, V
    FRANZ, CG
    JACOBS, AJ
    WEISS, JF
    YOUNG, RW
    PHARMACOLOGY & THERAPEUTICS, 1988, 39 (1-3) : 93 - 95
  • [48] SURVIVAL OF BONE MARROW-ENGRAFTED MICE SUBSEQUENT TO PROTECTION FROM LETHAL RADIATION BY WR-2721
    KINNAMON, KE
    KETTERLING, LL
    LEDNEY, GD
    LORENZ, GB
    MIODUSZEWSKI, RJ
    STAMPFLI, HF
    RADIATION RESEARCH, 1980, 82 (01) : 215 - 219
  • [49] CHEMO-PROTECTION AGAINST FRACTIONATED RADIATION EXPOSURES WITH WR-2721 - SKIN INJURY
    ECHOLS, FS
    YUHAS, JM
    RADIATION RESEARCH, 1976, 66 (03) : 499 - 504
  • [50] THE EFFECT OF COMBINATION OF RADIATION AND CHEMOTHERAPEUTIC-AGENTS AND PROTECTION AGAINST DAMAGE BY WR-2721
    ITO, H
    HASHIMOTO, S
    INAYAMA, S
    JOURNAL OF RADIATION RESEARCH, 1985, 26 (01) : 15 - 15
12345