Gastrointestinal infections caused by cytomegalovirus

被引：25
作者：
David A. Bobak
机构：
[1] Division of Infectious Diseases, University Hospitals of Cleveland, Case W. Reserve Univ. School of Med., Cleveland, OH 44106-5083
来源：
Current Infectious Disease Reports | 2003年 / 5卷 / 2期
关键词：
Transplant Recipient; Ganciclovir; Immunocompetent Patient; Cidofovir; Cytomegalovirus Infection;
D O I：
10.1007/s11908-003-0044-4
中图分类号：
学科分类号：
摘要：
Cytomegalovirus (CMV) is an important human pathogen, causing a variety of syndromes ranging from asymptomatic infections to life-threatening end-organ disease. Infections of the gastrointestinal tract are an especially common form of disease caused by CMV and are usually manifest as luminal infections, such as esophagitis or colitis. Solid organ disease caused by CMV is also known to occur, with hepatitis being the most commm syndrome. The large majority of cases of tissue-inyasive disease caused by CMV have been reported to occur in immunocompromised hosts. Patients at highest risk for serious CMV-mediated disease are commonly HIV infected, recipients of transplants, or are receiving potent immunosuppressive medications. Intriguingly, several recent reports have discussed the previously underappreciated role of serious forms of CMV-mediated disease occurring in immunocompetent patients. This paper reviews several recent reports addressing important aspects related to the diagnosis, treatment, and managament of CMV infections of the gastrointestinal tract. Copyright © 2003 by Current Science Inc.
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页码：101 / 107
页数：6
相关论文
共 53 条
  • [1] Pass R.F., Cytomegalovirus, Pediatr. Rev., 23, pp. 163-170, (2002)
  • [2] Sissons J.G.P., Carmichael A.J., Clinical aspects and management of cytomegalovirus infection, J. Infection, 44, pp. 78-83, (2002)
  • [3] Pass R.F., Cytomegalovirus, Fields Virology, pp. 2675-2706, (2001)
  • [4] Mocarski E.S., Courcelle C.T., Cytomegaloviruses and their replication, Fields Virology, pp. 2629-2674, (2001)
  • [5] Mocarski E.S., Immunomodulation by cytomegaloviruses: Manipulative strategies beyond evasion, Trends Microbiol., 10, pp. 332-339, (2002)
  • [6] Beisser P.S., Goh C.S., Cohen F.E., Michelson S., Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors, Curr. Top Microbiol. Immunol., 269, pp. 203-234, (2002)
  • [7] Miller D.M., Cebulla C.M., Sedmark D.D., Human cytomegalovirus inhibition of major histocompatibility complex transcription and interferon signal transduction, Curr. Top Microbiol. Immunol., 269, pp. 153-170, (2002)
  • [8] Grangeot-Keros L., Cointe D., Diagnosis and prognostic markers of HCMV infection, J. Clin. Virol., 21, pp. 213-221, (2001)
  • [9] Razonable R.R., Rivero A., Rodriguez A., Et al., Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients, J. Clin. Microbiol., 40, pp. 746-752, (2002)
  • [10] Singh N., Cytomegalovirus infection of liver transplant recipients: Comparison of antigenemia and molecular biology assays, Liver Transplant, 7, pp. 1004-1007, (2001)
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