Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

被引：0
作者：
Angel Varela-Rohena
Peter E Molloy
Steven M Dunn
Yi Li
Megan M Suhoski
Richard G Carroll
Anita Milicic
Tara Mahon
Deborah H Sutton
Bruno Laugel
Ruth Moysey
Brian J Cameron
Annelise Vuidepot
Marco A Purbhoo
David K Cole
Rodney E Phillips
Carl H June
Bent K Jakobsen
Andrew K Sewell
James L Riley
机构：
[1] University of Pennsylvania School of Medicine,Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine
[2] Immunocore Ltd.,Department of Medical Biochemistry and Immunology
[3] The Peter Medawar Building for Pathogen Research,undefined
[4] University of Oxford,undefined
[5] Henry Wellcome Building,undefined
[6] Cardiff University School of Medicine,undefined
[7] Adaptimmune Ltd.,undefined
来源：
Nature Medicine | 2008年 / 14卷
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摘要：
In HIV research, new types of reagents are needed to target infected cells and overcome HIV's ability to vary its HLA-I-restricted antigens and escape from host cytotoxic T lymphocytes. Here Varela-Rohena and colleagues use phage display technology to generate high-affinity T-cell antigen receptors that recognize common epitope-escape variants of the immunodominant HLA-A*02-restricted, HIVgag-specific peptide SLYNTVATL (SL9).
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页码：1390 / 1395
页数：5
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