Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells In Vitro and In Vivo

被引：0
|
作者：
M. A. Aleksandrova
G. T. Sukhikh
R. K. Chailakhyan
O. V. Podgornyi
M. V. Marei
R. A. Poltavtseva
Yu. V. Gerasimov
机构：
[1] Russian Academy of Sciences,Institute of Developmental Biology
[2] Russian Academy of Medical Sciences,Center of Obstetrics, Gynecology, and Perinatology
[3] N. F. Gamaleya Institute of Epidemiology and Microbiology,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2006年 / 141卷
关键词：
neural stem cells; mesenchymal stem cells; differentiation; filament growth; immunohistochemistry;
D O I：
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中图分类号：
学科分类号：
摘要：
Comparative analysis of differentiation of human neural and mesenchymal stem cells in tissue culture and after transplantation into the brain was carried out using the same antibody set. Neural stem cells differentiated into all types of neural cells, are retained after transplantation, migrate, and form reciprocal relationships with the recipient brain. Mesenchymal stem cells were incapable of neural development under conditions of common culturing or after transplantation and retained the fibroblast-like status. Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation.
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页码：152 / 160
页数：8
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