Sequence-specific 1H, 13C, and 15N resonance assignments of Diva (Boo), an apoptosis regulator of the Bcl-2 family

被引：0
作者：
Lorenzo Sborgi
Eva de Alba
机构：
[1] Consejo Superior de Investigaciones Científicas,Department of Chemical and Physical Biology, Centro de Investigaciones Biológicas
来源：
Biomolecular NMR Assignments | 2010年 / 4卷
关键词：
Apoptosis; Bcl-2 family; Diva (Boo); NMR;
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学科分类号：
摘要：
Diva, also known as Boo, is a member of the Bcl-2 family that regulates apoptosis by interacting with other Bcl-2 proteins and with the key component of the apoptosome Apaf-1. The function of Diva is puzzling as it apparently can both promote and inhibit apoptosis depending on the cellular context. The structural characterization of Diva will likely help to understand this dual behavior in programmed cell death. To this aim we report here the NMR resonance assignments of residues 1–160 of mouse Diva (lacking the predicted transmembrane domain, which spans residues 161–191). These data are used to obtain information on Diva’s secondary structure and provide the basis for further structural studies.
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页码：65 / 68
页数：3
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