Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis

被引：0

作者：

Peng Shi

Li Yu

Yun-xin Fu

Jing-Fei Huang

Ke-Qin Zhang

Ya-ping Zhang

机构：

[1] Laboratory of Cellular and Molecular Evolution,

[2] and Molecular Biology of Domestic Animals,undefined

[3] Kunming Institute of Zoology,undefined

[4] Chinese Academy of Sciences,undefined

[5] Laboratory for Conservation and Utilization of Bio-resource,undefined

[6] Yunnan University,undefined

[7] Human Genetics Center,undefined

[8] University of Texas at Houston,undefined

来源：

Cell Research | 2006年 / 16卷

关键词：

Avian Infectious Bronchitis Virus; SARS Coronavirus; positive selection; adaptive evolution; vaccine development;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus (SARS-CoV) was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines.

引用

页码：323 / 327

页数：4

共 48 条

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