Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study

被引：0

作者：

Gülçin Otar Yener

Ayşenur Paç Kısaarslan

Kadir Ulu

Erdal Atalay

Fatih Haşlak

Semanur Özdel

Burcu Bozkaya Yücel

Deniz Gezgin Yıldırım

Figen Çakmak

Kübra Öztürk

Mustafa Çakan

Zeynep Balık

Canan Hasbal Akkuş

Mehmet Yıldız

Tuğba Erat

Benhur Şirvan Çetin

Münevver Yılmaz

Esra Bağlan

Sibel Laçinel Gürlevik

Vildan Atasayan

Şerife Gül Karadağ

Amra Adrovic

Şengül Çağlayan

Ayşe Tanatar

Fatma Gül Demirkan

Taner Coşkuner

Özlem Akgün

Müşerref Kasap Cüceoğlu

Gülşah Kavrul Kayaalp

Sezgin Şahin

Özge Başaran

Ferhat Demir

Kenan Barut

Murat Çiftel

Dolunay Gürses

Ali Baykan

Yasemin Özsürekçi

Tevfik Karagöz

Hafize Emine Sönmez

Yelda Bilginer

Nuray Aktay Ayaz

Özlem Aydoğ

Selçuk Yüksel

Betül Sözeri

Özgür Kasapçopur

Seza Özen

机构：

[1] Şanlıurfa Research and Training Hospital,Department of Pediatric Rheumatology

[2] Erciyes University,Pediatric Rheumatology, Faculty of Medicine

[3] University of Health Sciences,Pediatric Rheumatology

[4] Ümraniye Research and Training Hospital,Pediatric Rheumatology, Faculty of Medicine

[5] Hacettepe University,Pediatric Rheumatology, Cerrahpaşa Faculty of Medicine

[6] İstanbul University-Cerrahpaşa,Pediatric Rheumatology

[7] University of Health Sciences,Pediatric Rheumatology, Faculty of Medicine

[8] Dr. Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital,Pediatric Rheumatology

[9] Ondokuz Mayis University,Pediatric Rheumatology, Faculty of Medicine

[10] Diyarbakır Training and Research Hospital,Pediatric Rheumatology

[11] Istanbul University,Pediatric Rheumatology

[12] Istanbul Medeniyet University,Pediatrics

[13] Göztepe Prof. Dr. Süleyman Yalçın City Hospital,Pediatric Infectious Diseases

[14] University of Health Sciences,Pediatric Infectious Diseases, Faculty of Medicine

[15] Zeynep Kamil Women and Children’s Diseases Training and Research Hospital,Pediatric Cardiology, Faculty of Medicine

[16] University of Health Sciences,Pediatric Infectious Diseases, Faculty of Medicine

[17] Ümraniye Research and Training Hospital,Pediatric Cardiology

[18] Şanlıurfa Research and Training Hospital,Pediatric Rheumatology

[19] Erciyes University,Pediatric Cardiology

[20] Pamukkale University,Pediatric Cardiology, Faculty of Medicine

[21] Hacettepe University,Pediatric Cardiology, Faculty of Medicine

[22] University of Health Sciences,Pediatric Rheumatology, Faculty of Medicine

[23] Ümraniye Research and Training Hospital,Pediatric Rheumatology, Faculty of Medicine

[24] Erzurum Regional Research and Training Hospital,undefined

[25] Şanlıurfa Research and Training Hospital,undefined

[26] Erciyes University,undefined

[27] Hacettepe University,undefined

[28] Kocaeli University,undefined

[29] Pamukkale University,undefined

来源：

Rheumatology International | 2022年 / 42卷

关键词：

Multisystem inflammatory syndrome in children (MIS-C); Kawasaki disease (KD); Macrophage activation syndrome; Systemic juvenile idiopathic arthritis;

D O I：

暂无

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学科分类号：

摘要：

To compare the clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C), patients with Kawasaki disease (KD) and with macrophage activating syndrome due to systemic juvenile idiopathic arthritis (sJIA-MAS) on real-life data. Patients diagnosed with MIS-C, KD, and sJIA-MAS from 12 different centers in Turkey who were followed for at least 6 months were included in the study. Demographic, clinical, and laboratory findings of all patients were analyzed. A total of 154 MIS-C, 59 KD, and 31 sJIA-MAS patients were included. The median age of patients with MIS-C were higher than those with KD while lower than those with sJIA-MAS (8.2, 3, 12 years, respectively). Myalgia (39.6%), cardiac (50.6%), gastrointestinal (72.7%), and neurological (22.1%) involvements were more common in patients with MIS-C compared to others. MIS-C patients had lower levels of lymphocyte (950 vs 1700 cells/µl) and thrombocyte (173,000 vs 355,000 cells/µl) counts and higher pro-BNP (1108 vs 55 pg/ml) levels than KD. Ferritin levels were higher in patients with MIS-C compared to patients with KD while they were lower than patients with sJIA-MAS (440, 170, 10,442 ng/ml, respectively). Patients with MIS-C had a shorter duration of hospitalization than sJIA-MAS (p = 0.02) while they required intensive care unit admission more frequently (55 vs 8 patients, p < 0.001). The median MAS/sJIA score of MIS-C patients was − 1.64 (− 5.23 to 9.68) and the median MAS/sJIA score of sJIA-MAS patients was −2.81 ([− 3.79] to [− 1.27]). MIS-C patients displayed certain differences in clinical and laboratory features when compared to KD and sJIA-MAS. Definition of the differences and similarities between MIS-C and the other intense inflammatory syndromes of childhood such as KD and MAS will help the clinicians while making timely diagnosis.

引用

页码：879 / 889

页数：10