23 years of the discovery of Helicobacter pylori: Is the debate over?

被引:54
作者
Ahmed N. [1 ]
机构
[1] Pathogen Evolution Group and ISOGEM Collaborative Network on Genetics of Helicobacters, International Society for Genomic and Evolutionary Microbiology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad
关键词
D O I
10.1186/1476-0711-4-17
中图分类号
学科分类号
摘要
The Gram negative curved bacillus H. pylori has become the prize bug of all times. Barry Marshall and Robin Warren the two discoverers of this organism have been awarded with this year's Nobel Prize. The Nobel committee at the Karolinska Institute of Sweden has selected this paradigm shift discovery of 1982 as the most impacting in medical sciences. This award has surprised many as the Nobel assembly has selected this 'Robert Koch styled medical detective work' for the prize as compared to many outstanding basic research stories on the waitlist. This editorial briefly touches the significant impact of H. pylori on gastroduodenal management and the path forward as the bug has become quite controversial in recent times. © 2005 Ahmed, licensee BioMed Central Ltd.
引用
收藏
页数:9
相关论文
共 13 条
[1]  
Dunn B.E., Cohen H., Blaser M.J., Helicobacter pylori, Clin. Microbiol. Rev., 10, pp. 720-741, (1997)
[2]  
Blaser M.J., An endangered species in the stomach, Sci. Am., 292, pp. 38-45, (2005)
[3]  
Marshall B.J., Warren R.M., Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration, Lancet, 16, pp. 1311-1315, (1984)
[4]  
Marshall B.J., Armstrong J.A., McGechie D.B., Glancy R.J., Attempt to fulfill Koch's postulates for pyloric campylobacter, Medical J. Australia, 142, pp. 436-439, (1985)
[5]  
Ahmed N., Sechi L.A., Helicobacter pylori and gastroduodenal pathology: New threats of the old friend, Ann. Clin. Microbiol. Antimicrobials, 4, (2005)
[6]  
Putsep K., Branden C.I., Boman H.G., Normark S., Antibacterial peptide from H. pylori, Nature, 398, pp. 671-672, (1999)
[7]  
Rothenbacher D., Blaser M.J., Bode G., Brenner H., Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: Results of a population-based cross-sectional study, J. Infect. Dis., 182, pp. 1446-1449, (2000)
[8]  
Richter J.E., Folk G.W., Vaezi M.F., Helicobacter pylori and gastroesophageal reflux disease: The bug may not be all bad, Am. J. Gastroenterol., 93, pp. 1800-1802, (1999)
[9]  
de Martel C., Llosa A.E., Farr S.M., Friedman G.D., Vogelman J.H., Orentreich N., Corley D.A., Parsonnet J., Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma, J. Infect. Dis., 191, pp. 761-767, (2005)
[10]  
Chow W.H., Blaser M.J., Blot W.J., Gammon M.D., Vaughan T.L., Risch H.A., Perez-Perez G.I., Schoenberg J.B., Stanford J.L., Rotterdam H., West A.B., Fraumeni Jr. J.F., An Inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma, Cancer Res., 58, pp. 588-590, (1998)