Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease

被引：0

作者：

Rhian S. Thomas

Alex Henson

Amy Gerrish

Lesley Jones

Julie Williams

Emma J. Kidd

机构：

[1] Cardiff University,School of Pharmacy and Pharmaceutical Sciences

[2] Cardiff University,MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine

[3] Birmingham Women’s NHS Foundation Trust,West Midlands Regional Genetics Laboratory

来源：

BMC Neuroscience | / 17卷

关键词：

Alzheimer’s disease; Amyloid precursor protein; β-C-terminal fragment; β-Secretase; Clathrin-mediated endocytosis; PICALM;

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