Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease

[1] Lambert JC(2009)Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease Nat Genet 41 1094-1099

[2] Heath S(2009)Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease Nat Genet 41 1088-1093

[3] Even G(2015)Convergent genetic and expression data implicate immunity in Alzheimer’s disease Alzheimer’s Dement 11 658-671

[4] Campion D(2013)Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease Nat Genet 45 1452-1458

[5] Sleegers K(2010)Genome-wide analysis of genetic loci associated with Alzheimer disease JAMA J Am Med Assoc 303 1832-1840

[6] Hiltunen M(1991)Amyloid deposition as the central event in the aetiology of Alzheimer’s disease Trends Pharmacol Sci 12 383-388

[7] Combarros O(1996)Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody J Cell Sci 109 991-998

[8] Zelenika D(1996)Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization J Cell Sci 109 999-1008

[9] Bullido MJ(1999)Purification and cloning of amyloid precursor protein beta-secretase from human brain Nature 402 537-540

[10] Tavernier B(1999)Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 735-741

[1] Lambert JC(2009)Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease Nat Genet 41 1094-1099

[2] Heath S(2009)Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease Nat Genet 41 1088-1093

[3] Even G(2015)Convergent genetic and expression data implicate immunity in Alzheimer’s disease Alzheimer’s Dement 11 658-671

[4] Campion D(2013)Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease Nat Genet 45 1452-1458

[5] Sleegers K(2010)Genome-wide analysis of genetic loci associated with Alzheimer disease JAMA J Am Med Assoc 303 1832-1840

[6] Hiltunen M(1991)Amyloid deposition as the central event in the aetiology of Alzheimer’s disease Trends Pharmacol Sci 12 383-388

[7] Combarros O(1996)Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody J Cell Sci 109 991-998

[8] Zelenika D(1996)Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization J Cell Sci 109 999-1008

[9] Bullido MJ(1999)Purification and cloning of amyloid precursor protein beta-secretase from human brain Nature 402 537-540

[10] Tavernier B(1999)Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 735-741