The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

被引:0
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作者
Yu-Chu Wang
Kung-Chao Chang
Bo-Wen Lin
Jenq-Chang Lee
Chien-Hsien Lai
Li-Jyuan Lin
Yun Yen
Chang-Shen Lin
Shiang-Jie Yang
Peng-Chan Lin
Chung-Ta Lee
Liang-Yi Hung
机构
[1] National Cheng-Kung University,Department of Biotechnology and Bioindustry Sciences
[2] National Cheng-Kung University,Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology
[3] National Cheng Kung University Hospital,Department of Pathology
[4] National Cheng Kung University Hospital,Department of Surgery
[5] Taipei Medical University,Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology
[6] Kaohsiung Medical University,Graduate Institute of Medicine, College of Medicine
[7] National Cheng Kung University,Institute of Basic Medical Sciences
[8] ,Department of Internal Medicine, College of Medicine
[9] National Cheng Kung University Hospital,undefined
来源
Experimental & Molecular Medicine | 2018年 / 50卷
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摘要
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many post-transcriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.
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页码:1 / 14
页数:13
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