When stem cells meet COVID-19: recent advances, challenges and future perspectives

被引：0
作者：
Shasha Li
Hecheng Zhu
Ming Zhao
Weidong Liu
Lei Wang
Bin Zhu
Wen Xie
Cong Zhao
Yao Zhou
Caiping Ren
Hui Liu
Xingjun Jiang
机构：
[1] Central South University,Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital
[2] Changsha Kexin Cancer Hospital,The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine
[3] Central South University,School of Ophthalmology and Optometry and Eye Hospital
[4] Wenzhou Medical University,Department of Neurosurgery, Xiangya Hospital
[5] Central South University,undefined
来源：
Stem Cell Research & Therapy | / 13卷
关键词：
COVID-19; SARS-CoV-2; Stem cell threapy; MSCs; Organoid models;
D O I：
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学科分类号：
摘要：
Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory coronavirus 2 is currently spreading throughout the world with a high rate of infection and mortality and poses a huge threat to global public health. COVID-19 primarily manifests as hypoxic respiratory failure and acute respiratory distress syndrome, which can lead to multiple organ failure. Despite advances in the supportive care approaches, there is still a lack of clinically effective therapies, and there is an urgent need to develop novel strategies to fight this disease. Currently, stem cell therapy and stem cell-derived organoid models have received extensive attention as a new treatment and research method for COVID-19. Here, we discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.
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[11]  
Chan JF(2016)Epidemiology, genetic recombination, and pathogenesis of coronaviruses Trends Microbiol 24 221-574
[12]  
Yuan S(2016)A molecular arms race between host innate antiviral response and emerging human coronaviruses Virol Sin 31 275-1034
[13]  
Kok KH(2020)Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Emerg Microbes Infect 9 565-192
[14]  
To KK(2020)An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies Emerg Microbes Infect 9 1024-1418
[15]  
Chu H(2020)Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Lancet 395 185-46
[16]  
Yang J(2020)Syncytia formation by SARS-CoV-2-infected cells EMBO J 39 1417-506
[17]  
Rabaan AA(2021)Increased angiotensin-converting enzyme 2 and loss of alveolar type II cells in COVID-19-related acute respiratory distress syndrome Am J Respir Crit Care Med 204 33-265
[18]  
Al-Ahmed SH(2020)Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection Front Med 14 497-513
[19]  
Haque S(2020)Endothelial cell infection and endotheliitis in COVID-19 Lancet 395 263-e36
[20]  
Sah R(2021)An Immuno-cardiac model for macrophage-mediated inflammation in COVID-19 Hearts Circ Res 129 507-919
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