Metabolic and endocrinologic complications in beta-thalassemia major: A multicenter study in Tehran

被引：0

作者：

Alireza Abdollah Shamshirsaz

Mir Reza Bekheirnia

Mohammad Kamgar

Nima Pourzahedgilani

Navid Bouzari

Mohammadreza Habibzadeh

Reza Hashemi

Amirhooshang Abdollah Shamshirsaz

Shahriar Aghakhani

Hooman Homayoun

Bagher Larijani

机构：

[1] Endocrinol./Metabol. Res. Center, Tehran Univ. Med. Sci. Health Serv., Tehran

[2] Shahid Behesti University, Medical Sciences and Health Services

来源：

BMC Endocrine Disorders | / 3卷 / 1期

关键词：

Bone Mineral Density; Serum Ferritin; Iron Overload; Hypogonadism; Thalassemia;

D O I：

10.1186/1472-6823-3-4

中图分类号：

学科分类号：

摘要：

Background: The combination of transfusion and chelation therapy has dramatically extended the life expectancy of thalassemic patients. The main objective of this study is to determine the prevalence of prominent thalassemia complications. Methods: Two hundred twenty patients entered the study. Physicians collected demographic and anthropometric data and the history of therapies as well as menstrual histories. Patients have been examined to determine their pubertal status. Serum levels of 25(OH) D, calcium, phosphate, iPTH were measured. Thyroid function was assessed by T3, T4 and TSH. Zinc and copper in serum were determined by flame atomic absorption spectrophotometry. Bone mineral density (BMD) measurements at lumbar and femoral regions have been done using dual x-ray absorptiometry. The dietary calcium, zinc and copper intakes were estimated by food-frequency questionnaires. Results: Short stature was seen in 39.3% of our patients. Hypogonadism was seen in 22.9% of boys and 12.2% of girls. Hypoparathyroidism and primary hypothyroidism was present in 7.6% and 7.7% of the patients. About 13 % of patients had more than one endocrine complication with mean serum ferritin of 1678 ± 955 micrograms/lit. Prevalence of lumbar osteoporosis and osteopenia were 50.7% and 39.4%. Femoral osteoporosis and osteopenia were present in 10.8% and 36.9% of the patients. Lumbar BMD abnormalities were associated with duration of chelation therapy. Low serum zinc and copper was observed in 79.6% and 68% of the study population respectively. Serum zinc showed significant association with lumbar but not femoral BMD. In 37.2% of patients serum levels of 25(OH) D below 23 nmol/l were detected. Conclusion: High prevalence of complications among our thalassemics signifies the importance of more detailed studies along with therapeutic interventions. © 2003 Abdollah Shamshirsaz et al; licensee BioMed Central Ltd.

引用

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