Elevation of Corazol-Induced Seizure Threshold after Active Immunization of Mice of Various Genetic Strains with Glutamate-Bovine Serum Albumin Conjugate

被引：0

作者：

M. N. Karpova

L. A. Vetrile

N. Yu. Klishina

N. A. Trekova

L. V. Kuznetsova

V. A. Evseev

机构：

[1] Institute of General Pathology and Pathophysiology,Laboratory of Functional Neurochemistry, Laboratory of Neuroimmunopathology

[2] Russian Academy of Medical Sciences,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2003年 / 136卷

关键词：

glutamate; antibodies; epileptiform activity; seizures; corazol;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the effect of active immunization with glutamate-bovine serum albumin conjugate on acute generalized epileptiform activity evoked by single administration of corazol. Antibodies to glutamate produced an antiepileptic effect and elevated the threshold for clonic seizures and tonic phase of lethal seizures. In BALB/c mice this effect was more pronounced than in C57BL/6 mice.

引用

页码：250 / 252

页数：2

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