Ocular Pharmacokinetic/Pharmacodynamic Modeling for Bunazosin After Instillation into Rabbits

被引：0
作者：
Koji Sakanaka
Kouichi Kawazu
Masahide Tomonari
Takashi Kitahara
Mikiro Nakashima
Shigeru Kawakami
Koyo Nishida
Junzo Nakamura
Hitoshi Sasaki
机构：
[1] Nagasaki University School of Medicine,Department of Hospital Pharmacy
[2] Santen Pharmaceutical Co.,Graduate School of Biomedical Sciences
[3] Ltd.,undefined
[4] Nara Research and Development Center,undefined
[5] Nagasaki University,undefined
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
bunazosin; eye; indirect response; intraocular pressure; pharmacokinetic/pharmacodynamic model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To develop a pharmacokinetic/pharmacodynamic (PK/PD) model for an α1-blocker (bunazosin) after instillation. The PK/PD model can predict both the drug concentrations in various ocular tissues and the hypotensive effect.
引用
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页码：770 / 776
页数：6
相关论文
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