S-Sulfo-Cysteine is an Endogenous Amino Acid in Neonatal Rat Brain but an Unlikely Mediator of Cysteine Neurotoxicity

被引：0
作者：
Abdul-Karim Abbas
Wanlin Xia
Mattias Tranberg
Holger Wigström
Stephen G. Weber
Mats Sandberg
机构：
[1] Goteborg University,Institute of Neuroscience and Physiology
[2] University of Pittsburgh,Department of Chemistry, Chevron Science Center
[3] Goteborg University,Institute of Biomedicine
来源：
Neurochemical Research | 2008年 / 33卷
关键词：
S-Sulfo-cysteine (SSC); Cysteine (Cys); Neurotoxicity; Cerebral cortex; Organotypic hippocampus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
S-sulfo-cysteine (SSC) is an agonist of glutamate receptors which could be involved in cysteine-induced neurotoxicity. Here we analyzed SSC by HPLC and demonstrated that the concentration of SSC in cortex of cysteine-injected rats increased to 1.4 μM, about four times the value of control rats. The neurotoxic effect of SSC was evaluated in slice cultures of rat hippocampus and compared to NMDA and cysteine. The neurotoxicity threshold of SSC was well above the tissue concentration. Our results show that SSC increases in neonatal rat brain after cysteine injection but reaches a tissue concentration far below concentrations that induce neurotoxicity in vitro. Thus, even if all the tissue SSC after cysteine injection was extracellular it would be below the threshold for toxicity, indicating that SSC is not a main excitotoxin involved in cysteine toxicity.
引用
收藏
页码：301 / 307
页数：6
相关论文
共 175 条
  • [1] Olney JW(1970)Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine Nature 227 609-611
  • [2] Ho OL(1971)Cytotoxic effects of acidic and sulfur containing amino acids on the infant mouse central nervous system Exp Brain Res 14 61-76
  • [3] Olney JW(1972)Cysteine-induced brain damage in infant and fetal rodents Brain Res 45 309-313
  • [4] Ho OL(1990)L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin Science 248 596-599
  • [5] Rhee V(1975)Brain damage and associated behavioral deficit following the administration of L-cysteine to infant rats Pharmacol Biochem Behav 3 291-298
  • [6] Olney JW(1989)Is a certain amount of cysteine prerequiste to produce brain damage in neonatal rats Neurochem Res 14 253-257
  • [7] Ho OL(1992)Changes in neurotransmitter parameters in the brain induced by L-cysteine injections in the young rat Brain Res 579 74-78
  • [8] Rhee V(1985)Hallervordon-Spatz disease: cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus Ann Neurol 18 482-489
  • [9] Schainker B(1990)Plasma cysteine and sulphate levels in patients with Motor neuron, Parkinson’s and Alzheimer’s disease Neurosci Lett 110 216-220
  • [10] Olney JW(1991)Cystine, sulfate, and ALS Neurological 41 1851-1852
12345678910