Comparison of temporal changes in psychological distress after hematopoietic stem cell transplantation among the underlying diseases of Japanese adult patients

被引：3

作者：

Fukuo W. ^{[1
]}

Yoshiuchi K. ^{[1
]}

Takimoto Y. ^{[1
]}

Sakamoto N. ^{[1
]}

Kikuchi H. ^{[1
]}

Hachizuka M. ^{[1
]}

Inada S. ^{[1
]}

Nannya Y. ^{[2
]}

Kumano K. ^{[3
]}

Takahashi T. ^{[2
]}

Kurokawa M. ^{[2
,3
]}

Akabayashi A. ^{[1
]}

机构：

[1] Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo

[2] Department of Hematology/Oncology, University of Tokyo, Tokyo

[3] Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo

来源：

BioPsychoSocial Medicine | / 2卷 / 1期

关键词：

Psychological Distress; Hematopoietic Stem Cell Transplantation; Hematological Malignancy; Acute Leukemia; Myelodysplastic Syndrome;

D O I：

10.1186/1751-0759-2-24

中图分类号：

学科分类号：

摘要：

Background: Although hematopoietic stem cell transplantation (HSCT) can potentially cure some hematological malignancies, patients who undergo HSCT experience psychological distress. However, there have been few studies on the short-term influence of HSCT on psychological distress. Methods: The subjects were 71 patients with hematological malignancies who underwent HSCT: 33 with acute leukemia, 19 with chronic leukemia, nine with myelodysplastic syndrome, and 10 with malignant lymphoma. Psychological distress was assessed prior to HSCT and on the seventh day after HSCT using the Profile of Mood States (POMS). Results: With regard to Anger-Hostility, the interaction of time (pre- and post-HSCT) and group (the four groups) was significant in male patients (p = 0.04), but not in female patients. With regard to the other subscales of POMS, there was no significant main effect or interaction in male or female patients. Conclusion: It may be important to provide psychological support to patients throughout the period of HSCT in consideration of differences in mood changes associated with the underlying disease and patient sex in order to provide efficient psychiatric intervention for both better psychiatric and survival outcomes. © 2008 Fukuo et al; licensee BioMed Central Ltd.

引用

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