Glucagon Like Peptide-1 is Protective Against Myocardial Ischemia/Reperfusion Injury when Given Either as a Preconditioning Mimetic or at Reperfusion in an Isolated Rat Heart Model

被引:0
作者
Amal K. Bose
Mihaela M. Mocanu
Richard D. Carr
Derek M. Yellon
机构
[1] University College London Hospital & Medical School,The Hatter Institute and Centre for Cardiology
[2] Novo Allé,NovoNordisk A/S
[3] University College London Hospital and Medical School,The Hatter Institute and Centre for Cardiology
来源
Cardiovascular Drugs and Therapy | 2005年 / 19卷
关键词
Glucagon like peptide-1; preconditioning; reperfusion injury; RISK pathway;
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页码:9 / 11
页数:2
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[1]  
Brubaker PL(2004)Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system Endocrinology 145 2653-2659
[2]  
Drucker DJ(2002)Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes J Endocrinol 173 465-473
[3]  
Luque MA(2004)Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion Circulation 109 962-965
[4]  
Gonzalez N(2004)Glucagon-like peptide-1 (GLP-1) protects the heart against ischaemia by activating glycoclysis Cardiovasc J S Afr 15 S15-578
[5]  
Marquez L(2003)Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium Peptides 24 569-151
[6]  
Nikolaidis LA(2005)Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury Diabetes 54 146-460
[7]  
Mankad S(2004)New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase(RISK)-pathway Cardiovasc Res 61 448-668
[8]  
Sokos GG(2002)PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning J Mol Cell Cardiol 34 661-398
[9]  
Huisamen B(2004)Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle J Endocrinol 180 389-198
[10]  
Genade S(1999)Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart Basic Res Cardiol 94 188-1198