Pyridazine and its related compounds. Part 34. Hypoglycemic and hypolipidemic activity of some novel condensed pyridazine sulfonamides

被引：0
作者：
Ali Deeb
Wafaa El-Eraky
Sally El-Awdan
Sebaey Mahgoub
机构：
[1] Zagazig University,Department of Chemistry, Faculty of Science
[2] National Research Centre,Department of Pharmacology
来源：
Medicinal Chemistry Research | 2014年 / 23卷
关键词：
Pyridazine; Triazolopyridazine; Sulfonamide; Sulfonylurea; Hypoglycemic activity; Hypolipidemic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel class of sulfonylurea and thiourea derivatives substituted with pyridazine and triazolopyridazine were designed and synthesized. The target compounds were assayed for their effects on the insulin release of alloxan-induced diabetic rats. The results showed that derivatives 4a, 4c, 8a, 11a, and 11b have significant antihyperglycemic effect in an experimental model of diabetes mellitus. No significant differences in cholesterol levels were observed between the diabetic group and diabetic groups that received the test compounds. However, the triglycerides level was reduced significantly by compound 8a when compared with the diabetic group.
引用
收藏
页码：34 / 41
页数：7
相关论文
共 55 条
[1]  
Costantino L(2000)Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives Farmaco 55 544-552
[2]  
Rastelli G(1991)Synthesis and evaluation of the aldose reductase inhibitory activity of new diaryl pyridazine-3-ones J Pharm Belg 46 375-380
[3]  
Vescovini K(1990)Studies on polyazaindenes synthesis of several new condensed pyridazine derivatives collect Czech Chem Commun 55 2795-2799
[4]  
Cignarell G(2005)Pyridazine derivatives and related compounds, part 8: synthesis of different heterocycles from 3-hydrazinopyridazine Heteroat Chem 12 278-282
[5]  
Barlocoo D(1999)Pharmacologic therapy for type 2 diabetes mellitus Ann Intern Med 131 281-303
[6]  
Coudert P(1983)New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus Am J Med 74 52-81
[7]  
Duroux E(2009)Pyridazine derivatives and related compounds, part 28.1 pyridazinesulfonamides: synthesis and antimicrobial activity phosphorus Sulfur Silicon 184 92-102
[8]  
Bastide P(2011)Synthesis and biological evaluation of new 3-trifluoromethylpyrazolesulfonyl-urea and thiourea derivatives as antidiabetic and antimicrobial agents J Fluor Chem 132 75-146
[9]  
Couquelet J(1982)Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide Clin Chem 28 2077-2080
[10]  
Tronche P(2012)Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties Bioorg Med Chem Lett 22 436-439
123456