Transplantation for type 1 diabetes: Whole organ pancreas and islet cells

被引：6

作者：

Pavlakis M. ^{[1
]}

Khwaja K. ^{[1
]}

机构：

[1] Beth Israel Deaconess Medical Center, The Transplant Center, Boston, MA 02215

来源：

Current Diabetes Reports | 2006年 / 6卷 / 6期

关键词：

Pancreas Transplantation; Exogenous Insulin; Insulin Independence; Simultaneous Pancreas Kidney; Enteric Drain;

D O I：

10.1007/s11892-006-0082-z

中图分类号：

学科分类号：

摘要：

β-Cell transplantation can be either a whole organ pancreas transplant or an islet cell transplant; both have resulted in restoration of a normoglycemic state. These transplants can be performed in conjunction with kidney transplants or as solitary grafts. In general, whole organ transplants have more sustained and durable function and are more widely available than their islet counterparts, but entail a much more invasive procedure. β-Cell transplantation continues to evolve, with considerable improvement in results over the past two decades, and is a cost-effective option for select patients with type 1 diabetes. Copyright © 2006 by Current Science Inc.

引用

页码：473 / 478

页数：5

共 33 条

[1]

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus, N Engl J Med, 329, pp. 977-986, (1993)

[2]

International Pancreas Transplant Registry: 2003 Annual Report, (2006)

[3]

Collaborative Islet Transplant Registry: 2005 Annual Report, (2006)

[4]

Gruessner A.C., Sutherland D.E.R., Analysis of United States (US) and non-US pancreas transplants reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant registry (IPTR) as of October 2001, Clinical Transplants 2001, pp. 41-72, (2002)

[5]

Fernandez L.A., Turgeon N.A., Odorico J.S., Et al., Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donors, Am J Transplant, 4, pp. 2093-2101, (2004)

[6]

Gross C.R., Zehrer C.L., Health-related quality of life outcomes of pancreas transplant recipients, Clin Transplant, 6, pp. 165-171, (1992)

[7]

Shapiro A.M.J., Lakey J.R.T., Ryan E.A., Et al., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid free immunosuppressive regimen, N Engl J Med, 343, pp. 230-238, (2000)

[8]

Scientific Registry of Transplant Recipients (SRTR): 2005 Annual Report, (2006)

[9]

Mazur M., Rea D., Griffin M.D., Et al., Decline in native renal function early after bladder-drained pancreas transplantation, Transplantation, 77, pp. 844-849, (2004)

[10]

Ojo A.O., Meier-Kriesche H.U., Hanson J.A., Et al., The impact of simultaneous pancreas-kidney transplantation on long-term patient survival, Transplantation, 71, pp. 82-90, (2001)

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