Cardiac reflections and natural vibrations: Force-frequency relation recording system in the stress echo lab

被引:8
作者
Bombardini T. [1 ]
Gemignani V. [2 ]
Bianchini E. [2 ]
Venneri L. [1 ]
Petersen C. [1 ]
Pasanisi E. [1 ]
Pratali L. [1 ]
Pianelli M. [1 ]
Faita F. [2 ]
Giannoni M. [2 ]
Picano E. [1 ]
机构
[1] Department of Echocardiography (Echo Lab.), IFC, CNR, Pisa
[2] Digital Signal Processing Lab. (DSPLAB), IFC, CNR, Pisa
关键词
Dipyridamole; Heart Sound; Arterial Elastance; Dipyridamole Stress; Isovolumic Contraction;
D O I
10.1186/1476-7120-5-42
中图分类号
学科分类号
摘要
Background. The inherent ability of ventricular myocardium to increase its force of contraction in response to an increase in contraction frequency is known as the cardiac force-frequency relation (FFR). This relation can be easily obtained in the stress echo lab, where the force is computed as the systolic pressure/end-systolic volume index ratio, and measured for increasing heart rates during stress. Ideally, the noninvasive, imaging independent, objective assessment of FFR would greatly enhance its practical appeal. Objectives. 1 - To evaluate the feasibility of the cardiac force measurement by a precordial cutaneous sensor. 2 - To build the curve of force variation as a function of the heart rate. 3 - To compare the standard stress echo results vs. this sensor operator-independent built FFR. Methods. The transcutaneous force sensor was positioned in the precordial region in 88 consecutive patients referred for exercise, dipyridamole, or pacing stress. The force was measured as the myocardial vibrations amplitude in the isovolumic contraction period. FFR was computed as the curve of force variation as a function of heart rate. Standard echocardiographic FFR measurements were performed. Results. A consistent FFR was obtained in all patients. Both the sensor built and the echo built FFR identifiy pts with normal or abnormal contractile reserve. The best cut-off value of the sensor built FFR was 15.5 g * 10-3 (Sensitivity = 0.85, Specificity = 0.77). Sensor built FFR slope and shape mirror pressure/volume relation during stress. This approach is extendable to daily physiological exercise and could be potentially attractive in home monitoring systems. © 2007 Bombardini et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 39 条
  • [1] Piot C., Lemaire S., Albat B., Seguin J., Nargeot J., Richard S., High frequency-induced upregulation of human cardiac calcium currents, Circulation, 93, pp. 120-128, (1996)
  • [2] Bowditch H.P., Über die Eigenthüm-lichkeiten der Reizbarkeit, welche die Muskelfasern des Herzens zeigen, Ber Sächs Akad Wiss, 23, pp. 652-689, (1871)
  • [3] Liu C.P., Ting C.T., Lawrence W., Maughan W.L., Chang M.S., Kass D.A., Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy: Systolic versus diastolic determinants, Circulation, 88, pp. 1893-1906, (1993)
  • [4] Hasenfuss G., Holubarsch C., Hermann H.P., Astheimer K., Pieske B., Just H., Influence of the force-frequency relationship on haemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy, Eur Heart J, 15, pp. 164-170, (1994)
  • [5] Bhargava V., Shabetai R., Mathiasen R.A., Dalton N., Hunter J.J., Ross Jr. J., Loss of adrenergic control of the force-frequency relation in heart failure secondary to idiopathic or ischemic cardiomyopathy, Am J Cardiol, 81, pp. 1130-1137, (1998)
  • [6] Inagaki M., Yokota M., Izawa H., Ishiki R., Nagata K., Iwase M., Yamada Y., Koide M., Sobue T., Impaired force-frequency relations in patients with hypertensive left ventricular hypertrophy, Circulation, 14, pp. 1822-1830, (1999)
  • [7] Gemignani V., Bianchini E., Faita F., Giannoni M., Pasanini E., Picano E., Bombardini T., Operator-independent force-frequency relation monitoring during stress with a new transcutaneous cardiac force sensor, Proc 34th Annual Conference of Computers in Cardiology, (2007)
  • [8] Sakamoto T., Kusukawa R., MacCanon D.M., Luisada A.A., Hemodynamic determinants of the amplitude of the first heart sound, Circ Res, 16, pp. 45-47, (1965)
  • [9] Bombardini T., Correia M.J., Cicerone C., Agricola E., Ripoli A., Picano E., Force-frequency Relationship in the Echocardiography Laboratory: A Noninvasive Assessment of Bowditch Treppe?, J Am Soc Echocardiogr, 16, pp. 646-655, (2003)
  • [10] Bombardini T., Agrusta M., Natsvlishvili N., Solimene F., Pap R., Coltorti F., Varga A., Mottola G., Picano E., Noninvasive assessment of left ventricular contractility by pacemaker stress echocardiography, Eur J Heart Failure, 2, pp. 173-181, (2005)