Autoimmune Thyroiditis (Hashimoto's Thyroiditis): Current Diagnostics and Therapy

被引:21
作者
Fink, Heike [1 ]
Hintze, Gerhard [1 ]
机构
[1] Asklepios Klin Bad Oldesloe, Med Klin, D-23843 Bad Oldesloe, Germany
关键词
TPO-AB; Hypothyroidism; Polyglandular syndrome 2; SUBCLINICAL HYPOTHYROIDISM; LONG-TERM; DYSFUNCTION; IODINE;
D O I
10.1007/s00063-010-1082-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hashimoto's thyroiditis is a common autoimmune thyroid disease with preference of female gender. The chronic thyroiditis is characterized by autoantibodies against thyroid peroxidase and thyroglobulin. With manifestation, there is often a subclinical hypothyroidism that finally progresses to a persistent hypothyroidism with typical clinical symptoms and the need of hormonal substitution in succession of the lymphocytic infiltration of the thyroid. The ultrasound of the thyroid shows a hypoechogenic and inhomogeneous parenchyma. Autoimmune thyroiditis is frequently associated with autoimmune disease of other organs, such as vitiligo, Addison's disease, diabetes mellitus type 1, often in the sense of polyglandular syndrome 2.
引用
收藏
页码:485 / 493
页数:9
相关论文
共 24 条
[1]   THE EFFECT OF IODIDE INGESTION ON THE DEVELOPMENT OF SPONTANEOUS LYMPHOCYTIC THYROIDITIS IN THE DIABETES-PRONE BB/W RAT [J].
ALLEN, EM ;
APPEL, MC ;
BRAVERMAN, LE .
ENDOCRINOLOGY, 1986, 118 (05) :1977-1981
[2]   The clinical significance of subclinical thyroid dysfunction [J].
Biondi, Bernadette ;
Cooper, David S. .
ENDOCRINE REVIEWS, 2008, 29 (01) :76-131
[3]   Prevalence and Relative Risk of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease [J].
Boelaert, Kristien ;
Newby, Paul R. ;
Simmonds, Matthew J. ;
Holder, Roger L. ;
Carr-Smith, Jacqueline D. ;
Heward, Joanne M. ;
Manji, Nilusha ;
Allahabadia, Amit ;
Armitage, Mary ;
Chatterjee, Krishna V. ;
Lazarus, John H. ;
Pearce, Simon H. ;
Vaidya, Bijay ;
Gough, Stephen C. ;
Franklyn, Jayne A. .
AMERICAN JOURNAL OF MEDICINE, 2010, 123 (02) :183.e1-183.e9
[4]   Ultrasonography of the thyroid and parathyroid gland [J].
Braun, B. ;
Blank, W. .
INTERNIST, 2006, 47 (07) :729-746
[5]  
BRAVERMAN LE, 2003, DIS THYROID CONT END
[6]   Thyroid Volume in Hypothyroidism due to Autoimmune Disease Follows a Unimodal Distribution: Evidence against Primary Thyroid Atrophy and Autoimmune Thyroiditis Being Distinct Diseases [J].
Carle, Allan ;
Pedersen, Inge Bulow ;
Knudsen, Nils ;
Perrild, Hans ;
Ovesen, Lars ;
Jorgensen, Torben ;
Laurberg, Peter .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (03) :833-839
[7]   Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis [J].
Duntas, LH ;
Mantzou, E ;
Koutras, DA .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (04) :389-393
[8]   Increased Circulating Pro-Inflammatory Cytokines and Th17 Lymphocytes in Hashimoto's Thyroiditis [J].
Figueroa-Vega, Nicte ;
Alfonso-Perez, Manuel ;
Benedicto, Ignacio ;
Sanchez-Madrid, Francisco ;
Gonzalez-Amaro, Roberto ;
Marazuela, Monica .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (02) :953-962
[9]  
Fink HJ, 2006, MED KLIN, V101, P645, DOI 10.1007/s00063-006-1094-9
[10]   THYROID AND OVARIAN-FUNCTION IN INFERTILE WOMEN [J].
GERHARD, I ;
BECKER, T ;
EGGERTKRUSE, W ;
KLINGA, K ;
RUNNEBAUM, B .
HUMAN REPRODUCTION, 1991, 6 (03) :338-345