Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities

被引：0
|
作者：
Xianglan Kong
Xinhua Ma
Yunying Xie
Shengxin Cai
Tianjiao Zhu
Qianqun Gu
Dehai Li
机构：
[1] School of Medicine and Pharmacy,Key Laboratory of Marine Drugs, Chinese Ministry of Education
[2] Ocean University of China,Institute of Medicinal Biotechnology
[3] Chinese Academy of Medical Sciences & Peking Union Medical College,undefined
来源：
Archives of Pharmacal Research | 2013年 / 36卷
关键词：
Sponge-derived fungus; Secondary metabolites; Naphtho-γ-pyrones; Diphenyl ethers; Antitubercular activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.
引用
收藏
页码：739 / 744
页数：5
相关论文
共 41 条
  • [31] New Dihydroisocoumarin Root Growth Inhibitors From the Sponge-Derived Fungus Aspergillus sp. NBUF87
    Huang, Liming
    Ding, Lijian
    Li, Xiaohui
    Wang, Ning
    Cui, Wei
    Wang, Xiao
    Naman, C. Benjamin
    Lazaro, J. Enrico H.
    Van, Xiaojun
    He, Shan
    FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [32] 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp HPQJ-34
    Fang, Fang
    Zhao, Jiaying
    Ding, Lijian
    Huang, Chunhui
    Naman, C. Benjamin
    He, Shan
    Wu, Bin
    Zhu, Peng
    Luo, Qijun
    Gerwick, William H.
    Yan, Xiaojun
    Wang, Qinwen
    Zhang, Zaijun
    Cui, Wei
    MARINE DRUGS, 2017, 15 (08):
  • [33] Anti-Inflammatory Polyketide Derivatives from the Sponge-Derived Fungus Pestalotiopsis sp. SWMU-WZ04-2
    Jiang, Peng
    Luo, Jinfeng
    Jiang, Yao
    Zhang, Liping
    Jiang, Liyuan
    Teng, Baorui
    Niu, Hong
    Zhang, Dan
    Lei, Hui
    MARINE DRUGS, 2022, 20 (11)
  • [34] Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413
    Ye, Yuxiu
    Liang, Jiaqi
    She, Jianglian
    Lin, Xiuping
    Wang, Junfeng
    Liu, Yonghong
    Yang, Dehua
    Tan, Yanhui
    Luo, Xiaowei
    Zhou, Xuefeng
    MARINE DRUGS, 2023, 21 (01)
  • [35] Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2
    Girich, Elena V.
    Trinh, Phan Thi Hoai
    Nesterenko, Liliana E.
    Popov, Roman S.
    Kim, Natalya Yu
    Rasin, Anton B.
    Menchinskaya, Ekaterina S.
    Kuzmich, Aleksandra S.
    Chingizova, Ekaterina A.
    Minin, Artem S.
    Ngoc, Ngo Thi Duy
    Van, Tran Thi Thanh
    Yurchenko, Ekaterina A.
    Yurchenko, Anton N.
    Berdyshev, Dmitry V.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [36] Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp SCSIO41007
    Pang, Xiaoyan
    Lin, Xiuping
    Wang, Junfeng
    Liang, Rui
    Tian, Yongqi
    Salendra, Limbadri
    Luo, Xiaowei
    Zhou, Xuefeng
    Yang, Bin
    Tu, Zhengchao
    Liu, Yonghong
    STEROIDS, 2018, 129 : 41 - 46
  • [37] New N-methyl-4-quinolone alkaloid and citrinin dimer derivatives from the sponge-derived fungus Penicillium sp. SCSIO 41303
    Guo, Tian-Tian
    Song, Meng-Meng
    Han, Wen-Rong
    Zhu, Jun-Heng
    Liu, Qing-Chao
    Wang, Jun-Feng
    PHYTOCHEMISTRY LETTERS, 2021, 46 : 29 - 35
  • [38] Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49
    Chen, Yaping
    Chen, Ruyan
    Xu, Jinhuai
    Tian, Yongqi
    Xu, Jiangping
    Liu, Yonghong
    MOLECULES, 2018, 23 (11):
  • [39] Targeted Discovery of Sorbicillinoid Pigments with Anti- Inflammatory Activity from the Sponge-Derived Fungus Stagonospora sp. SYSU-MS7888 Using the PMG Strategy
    Chen, Senhua
    Guo, Heng
    Wu, Zhenger
    Wu, Qilin
    Jiang, Minghua
    Li, Hanxiang
    Liu, Lan
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022, 70 (48) : 15116 - 15125
  • [40] New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1
    Cao, Min-Jia
    Zhu, Tao
    Liu, Jing-Tang
    Ouyang, Liang
    Yang, Fan
    Lin, Hou-Wen
    NATURAL PRODUCT RESEARCH, 2020, 34 (20) : 2880 - 2886
12345