Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities

被引：0
|
作者：
Xianglan Kong
Xinhua Ma
Yunying Xie
Shengxin Cai
Tianjiao Zhu
Qianqun Gu
Dehai Li
机构：
[1] School of Medicine and Pharmacy,Key Laboratory of Marine Drugs, Chinese Ministry of Education
[2] Ocean University of China,Institute of Medicinal Biotechnology
[3] Chinese Academy of Medical Sciences & Peking Union Medical College,undefined
来源：
Archives of Pharmacal Research | 2013年 / 36卷
关键词：
Sponge-derived fungus; Secondary metabolites; Naphtho-γ-pyrones; Diphenyl ethers; Antitubercular activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.
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页码：739 / 744
页数：5
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