Vascular endothelial growth factor-C and its receptor-3 signaling in tumorigenesis

被引：0
作者：
Selvaraj Vimalraj
Krishnasamy Naidu Gopal Hariprabu
Mostafizur Rahaman
Periyasami Govindasami
Karthikeyan Perumal
Saravanan Sekaran
Dhanraj Ganapathy
机构：
[1] Indian Institute of Technology,Department of Applied Mechanics and Biomedical Engineering
[2] Madras,Centre for Biotechnology
[3] Anna University,Department of Chemistry, College of Science
[4] King Saud University,Department of Chemistry and Biochemistry
[5] The Ohio State University,Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS)
[6] Saveetha University,undefined
来源：
3 Biotech | 2023年 / 13卷
关键词：
Tumor; VEGFR-3; VEGF-C; Lymphangiogenesis; Angiogenesis;
D O I：
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学科分类号：
摘要：
The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed by a range of human tumor cells in addition to lymphatic endothelial cells. Activating the VEGF-C/VEGFR-3 signaling enhances metastasis by promoting lymphangiogenesis and angiogenesis inside and around tumors. Stimulation of VEGF-C/VEGFR-3 signaling promotes tumor metastasis in tumors, such as ovarian, renal, pancreatic, prostate, lung, skin, gastric, colorectal, cervical, leukemia, mesothelioma, Kaposi sarcoma, and endometrial carcinoma. We discuss and update the role of VEGF-C/VEGFR-3 signaling in tumor development and the research is still needed to completely comprehend this multifunctional receptor.
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[41]  
Takeno S(2003)Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer Chin Med J 116 343-2372
[42]  
Chujo M(2004)Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in human prostate Prostate 58 11990-610
[43]  
Miura T(2019)VEGFR2 promotes tumorigenesis and metastasis in a pro-angiogenic-independent way in gastric cancer BMC Cancer 19 27617-89
[44]  
Uchida Y(2014)VEGFR3 inhibition chemosensitizes ovarian cancer stemlike cells through down-regulation of BRCA1 and BRCA2 Neoplasia (united States) 16 55-1890
[45]  
Baeyens N(2017)Autocrine VEGF signaling promotes cell proliferation through a PLC-dependent pathway and modulates Apatinib treatment efficacy in gastric cancer Oncotarget 8 2363-7
[46]  
Nicoli S(1999)Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi’s sarcoma cells J Biol Chem 274 603-474
[47]  
Coon BG(2013)Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer Cancer Genomics Proteomics 10 83-1219
[48]  
Ross TD(2005)Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages J Clin Invest 115 1877-225
[49]  
Van den Dries K(2003)Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops Int J Cancer 104 1-3364
[50]  
Han J(2022)Mechanoregulation of vascular endothelial growth factor receptor 2 in angiogenesis Front Cardiovasc Med 8 464-716
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