T1R3: A human calcium taste receptor

被引：0
作者：
Michael G. Tordoff
Laura K. Alarcón
Sitaram Valmeki
Peihua Jiang
机构：
[1] Monell Chemical Senses Center,
来源：
Scientific Reports | / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this and lactisole can reduce the taste perception of calcium by acting on T1R3.
引用
收藏
相关论文
共 52 条
  • [21] Romanov RA(2003)Different functional roles of T1R subunits in the heteromeric taste receptors Food. Qual. Pref. 14 111-124
  • [22] Rogachevskaja OA(2005)An overview of binary taste-taste interactions J. Biol. Chem. 280 34296-34305
  • [23] Churbanov GD(2004)Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3 J Vet Med Sci 66 1311-1314
  • [24] Kolesnikov SS(2004)Expression of the sweet receptor protein, T1R3, in the human liver and pancreas Appetite 43 1-3
  • [25] Ohsu T(2000)The sixth taste? Cell 100 703-711
  • [26] Henning H(2010)T2Rs function as bitter taste receptors Chem Senses 35 157-170
  • [27] Tordoff MG(2011)The molecular receptive ranges of human TAS2R bitter taste receptors Science 333 1262-1266
  • [28] Galindo-Cuspinera V(undefined)A gustotopic map of taste qualities in the mammalian brain undefined undefined undefined-undefined
  • [29] Breslin PA(undefined)undefined undefined undefined undefined-undefined
  • [30] Jiang P(undefined)undefined undefined undefined undefined-undefined
123456