Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

被引：134
作者：
Park J.-H. [1 ]
Shin H.-J. [1 ]
Kim M.H. [1 ]
Kim J.-S. [1 ]
Kang N. [1 ]
Lee J.-Y. [1 ]
Kim K.-T. [1 ]
Lee J.I. [1 ]
Kim D.-D. [1 ]
机构：
[1] College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul
来源：
Journal of Pharmaceutical Investigation | 2016年 / 46卷 / 4期
基金：
新加坡国家研究基金会;
关键词：
Adsorption; Bentonite; Cationic exchange; Delivery system; Drug release; Montmorillonite; Sustained release;
D O I：
10.1007/s40005-016-0258-8
中图分类号：
学科分类号：
摘要：
Montmorillonite is a multifunctional clay mineral and a major component of bentonite. Montmorillonite has been used in various industrial and pharmaceutical fields due to its unique characteristics, which include swelling and adsorption. The high adsorption capacity of montmorillonite contributes to increase drug entrapment and sustained-release of drugs. Montmorillonite generally sustains drug release in many formulations by strongly adsorbing to the drug. In addition, montmorillonite enhances the dissolution rate and bioavailability of hydrophobic drugs. Moreover, montmorillonite was applied to form composites with other polymer-based delivery systems. Thus, montmorillonite could be applied to formulate diverse drug delivery systems to control and/or improve the pharmaceutical properties of drugs, including solubility, dissolution rate, and absorption. In this review, perspectives of applying montmorillonite as a pharmaceutical excipient in drug delivery systems are discussed. © 2016, The Korean Society of Pharmaceutical Sciences and Technology.
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页码：363 / 375
页数：12
相关论文
共 124 条
[91]  
Mikhail R.S., Guindy N.M., Hanafi S., Vapor adsorption on expanding and nonexpanding clay minerals, J Colloid Interface Sci, 70, pp. 282-292, (1979)
[92]  
Monvisade P., Siriphannon P., Chitosan intercalated montmorillonite: preparation, characterization and cationic dye adsorption, Appl Clay Sci, 42, pp. 427-431, (2009)
[93]  
Mould D.R., Walz A.C., Lave T., Gibbs J.P., Frame B., Developing exposure/response models for anticancer drug treatment: special considerations, CPT Pharmacomet Syst Pharmacol, 4, (2015)
[94]  
Muzzarelli R., Baldassarre V., Conti F., Ferrara P., Biagini G., Gazzanelli G., Vasi V., Biological activity of chitosan: ultrastructural study, Biomaterials, 9, pp. 247-252, (1988)
[95]  
Namazi H., Belali S., Starch-g-lactic acid/montmorillonite nanocomposite: synthesis, characterization and controlled drug release study, Starch-Stärke, 67, pp. 1-11, (2015)
[96]  
Nho Y.C., Park J.S., Lim Y.M., Preparation of poly (acrylic acid) hydrogel by radiation crosslinking and its application for mucoadhesives, Polymers, 6, pp. 890-898, (2014)
[97]  
Norrish K., The swelling of montmorillonite, Discuss Faraday Soc, 18, pp. 120-134, (1954)
[98]  
Oh S.T., Kwon O.J., Chun B.C., Cho J.W., Park J.S., The effect of bentonite concentration on the drug delivery efficacy of a pH-sensitive alginate/bentonite hydrogel, Fiber Polym, 10, pp. 21-26, (2009)
[99]  
Onal M., Physicochemical properties of bentonites: an overview, Commun Fac Sci Univ Ank Ser B, 52, pp. 7-21, (2006)
[100]  
Pongjanyakul T., Suksri H., Alginate-magnesium aluminum silicate films for buccal delivery of nicotine, Colloids Surf B Biointerfaces, 74, pp. 103-113, (2009)
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