High-energy phosphate metabolism in normal, hypertrophied and failing human myocardium

被引：0

作者：

Neubauer S. ^{[1
,2
,3
]}

机构：

[1] Medizinische Universitätsklinik, Würzburg

[2] Dept. of Cardiovascular Medicine, John Raddiff Hospital, Oxford University

[3] Dept. of Cardiovascular Medicine, John Radcliff Hospital, Oxford OX 3 9DU, Headley Way

来源：

Heart Failure Reviews | 1999年 / 4卷 / 3期

关键词：

!sup]31[!/sup]P-MR spectroscopy; ATP; Creatine; High-energy phosphate metabolism; Human myocardium; Phosphocreatine;

D O I：

10.1023/A:1009866108384

中图分类号：

学科分类号：

摘要：

This chapter examines the role of cardiac high-energy phosphate metabolism in normal, hypertrophied and failing human myocardium. Myocardial biopsies allow analysis of ATP, total adenine nucleotides, creatine kinase activity and total creatine content, while non-invasive 31P-magnetic resonance spectroscopy can be used to determine phosphocreatine/ATP ratios and, most recently, absolute levels of ATP and phosphocreatine. The failing human myocardium is characterized by reduced phosphocreatine and total creatine levels, normal or slightly reduced ATP levels and reduced creatine kinase activity. These changes are consistent with, but do not prove, a role of high-energy phosphate metabolism as a contributing factor in heart failure. An answer to the precise functional role of high-energy phosphate metabolism necessitates analysis of free ADP levels, free energy change of ATP hydrolysis and creatine kinase reaction velocity; these measurements may become feasible in coming years. However, analysis of energy metabolism in a compartmentalized manner, i.e., in the compartments relevant for contractile function such as the perimyofibrillar space, will remain elusive for the foreseeable future.

引用

页码：269 / 280

页数：11

共 62 条

[21]

Auffermann W., Chew W.M., Wolfe C.L., Tavares N.J., Parmley W.W., Semelka R.C., Donnelly T., Chatterjee K., Higgins C.B., Normal and diffusely abnormal myocardium in humans: Functional and metabolic characterization with P-31 MR spectroscopy and cine MR imaging, Radiology, 179, pp. 253-259, (1991)

[22]

Bottomley P.A., Hardy C.J., Roemer P.B., Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance, Magn Reson Med, 14, pp. 425-434, (1990)

[23]

Bottomley P.A., Atalar E., Weiss R.G., Human cardiac high-energy phosphate metabolite concentrations by ID-resolved NMR spectroscopy, Magn Reson Med, 35, pp. 664-670, (1996)

[24]

Neubauer S., Krahe T., Schindler R., Hillenbrand H., Entzeroth C., Horn M., Bauer W.R., Stephan T., Lackner K., Haase A., Et al., Direct measurement of spin-lattice relaxation times of phosphorus metabolites in human myocardium, Magn Reson Med, 26, pp. 300-307, (1992)

[25]

Van Dobbenburgh J.O., Lekkerkerk C., Van Echteld C.J., De Beer R., Saturation correction in human cardiac 31P MR spectroscopy at 1.5 T, NMR Biomed, 7, pp. 218-224, (1994)

[26]

Hardy C.J., Bottomley P.A., Rohling K.W., Roemer P.B., An NMR phased array for human cardiac 31P spectroscopy, Magn Reson Med, 28, pp. 54-64, (1992)

[27]

Bottomley P.A., Hardy C.J., Mapping creatine kinase reaction rates in human brain and heart with 4 tesla saturation transfer 31P NMR, J Magn Reson, 99, pp. 443-448, (1992)

[28]

Ingwall J.S., Kramer M.F., Fifer M.A., Lorell B.H., Shemin R., Grossman W., Allen P.D., The creatine kinase system in normal and diseased human myocardium, N Engl J Med, 313, pp. 1050-1054, (1985)

[29]

Bottomley P.A., Weiss R.G., Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium, Lancet, 351, pp. 714-718, (1998)

[30]

Balaban R.S., Kantor H.L., Katz L.A., Briggs R.W., Relation between work and phosphate metabolite in the in vivo paced mammalian heart, Science, 232, pp. 1121-1123, (1986)

← 1 2 3 4 5 6 7 →