Rapid HPTLC Quantification of p-Aminobenzoic Acid in Complex Pharmaceutical Preparations

被引：0

作者：

Anna W. Sobanska

Elzbieta Brzezinska

机构：

[1] Medical University of Lodz,Department of Analytical Chemistry

来源：

JPC – Journal of Planar Chromatography – Modern TLC | 2010年 / 23卷

关键词：

-Aminobenzoic acid; Determination; HPTLC; Spectrodensitometry; reaction; ChromaJet DS20;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A particularly rapid HPTLC method has been established for chromatographic separation and quantification of p-aminobenzoic acid (PABA) in complex dietary supplement tablets. After chromatography, PABA was determined by spectrodensitometry at 270 nm. PABA spots were then visualized by a novel staining procedure involving the Bratton-Marshall coupling reaction after spraying with 8-hydroxyquinoline in situ on the chromatographic plates. After visualization, spectrodensitometric analysis was repeated at 500 nm. Linearity, intermediate precision, sensitivity, accuracy, and precision were compared for both methods. Results from tablet analysis were verified with the modified Bratton-Marshall spectrophotometric procedure.

引用

页码：141 / 147

页数：6

共 31 条

[21] Laccase-induced C–N coupling of substituted p-hydroquinones with p-aminobenzoic acid in comparison with known chemical routes
Annett Mikolasch
Anastasia Matthies
Michael Lalk
Frieder Schauer
Applied Microbiology and Biotechnology, 2008, 80 : 389 - 397
[22] A rapid densitometric method for simultaneous quantification of gallic acid and ellagic acid in herbal raw materials using HPTLC
Bagul, M
Srinivasa, H
Padh, H
Rajani, M
JOURNAL OF SEPARATION SCIENCE, 2005, 28 (06) : 581 - 584
[23] The effect of nitrate, bicarbonate and natural organic matter on the degradation of sunscreen agent p-aminobenzoic acid by simulated solar irradiation
Mao, Liang
Meng, Cui
Zeng, Chao
Ji, Yuefei
Yang, Xi
Gao, Shixiang
SCIENCE OF THE TOTAL ENVIRONMENT, 2011, 409 (24) : 5376 - 5381
[24] The relationship between self-organization, physicochemical properties, and biological activity of low-concentration solutions of p-aminobenzoic acid
O. A. Mishina
L. I. Murtazina
I. S. Ryzhkina
A. I. Konovalov
Russian Chemical Bulletin, 2015, 64 : 590 - 596
[25] Understanding and Designing Tailor-Made Additives for Controlling Nucleation: Case Study of p-Aminobenzoic Acid Crystallizing from Ethanolic Solutions
Kaskiewicz, Peter L.
Rosbottom, Ian
Hammond, Robert B.
Warren, Nicholas J.
Morton, Colin
Dowding, Peter J.
George, Neil
Roberts, Kevin J.
CRYSTAL GROWTH & DESIGN, 2021, 21 (04) : 1946 - 1958
[26] Direct condensation polymerization of N-alkylated p-aminobenzoic acid and packing of rigid-rod main chains with flexible side chains
Yuji Shibasaki
Yoko Abe
Natsuki Sato
Atsuhiro Fujimori
Yoshiyuki Oishi
Polymer Journal, 2010, 42 : 72 - 80
[27] Synthesis and crystal structures of three Schiff bases derived from 3-formylacetylacetone and o-, m- and p-aminobenzoic acid
Halz, Jan Henrik
Hentsch, Andreas
Wagner, Christoph
Merzweiler, Kurt
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2022, 78 : 54 - +
[28] Development and characterization of an ultrasensitive label-free electrochemical immunosensor for okadaic acid based on polydimer (p-aminobenzoic acid)-modified gold three-dimensional nanoelectrode ensembles
Huimin Nai
Lixin Cao
Shuai Sun
Rujin Li
Haiping Liu
Peisheng Yan
Ionics, 2021, 27 : 5323 - 5331
[29] SEPARATION AND QUANTIFICATION OF PHARMACOLOGICALLY ACTIVE MARKERS p-METHOXY BENZOIC ACID, 3, 4-DIHYDROXYBENZOIC ACID AND GALLIC ACID FROM CAPPARIS SPINOSA AND FROM MARKETED FORMULATION BY HPTLC
Vaidya, Vikas V.
Shinde, Manjiri A.
Pradhan, Pushkar M.
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (02): : 1226 - 1232
[30] Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine
A. A. Agekyan
G. G. Mkryan
Russian Journal of General Chemistry, 2015, 85 : 1057 - 1062

← 1 2 3 4 →