Synthesis of 4-trifluoromethyl-3,4-dihydro-1,3,5-triazino[2,1-a]isoindol-2-ones by cyclocondensation of 1-aryl-1-chloro-2,2,2-trifluoroethyl isocyanates with 3-amino-1-arylimino-1H-isoindoles

被引：0
作者：
A. V. Biitseva
O. V. Gordienko
M. Yu. Kornilov
V. A. Sukach
M. V. Vovk
O. V. Shishkin
V. V. D’yakonenko
机构：
[1] Taras Shevchenko Kiev National University,Institute of Organic Chemistry
[2] National Academy of Sciences of the Ukraine,Research and Technology Enterprise “Institute of Single Crystals”
[3] National Academy of Sciences of the Ukraine,undefined
来源：
Russian Journal of Organic Chemistry | 2007年 / 43卷
关键词：
Isocyanate; Torsion Angle; Phthalonitrile; Triazino; Trifluoromethyl Substituent;
D O I：
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学科分类号：
摘要：
4-Trifluoromethyl-3,4-dihydro-1,3,5-triazino[2,1-a]isoindol-2-ones were prepared by reaction of 1-aryl-1-chloro-2,2,2-trifluoroethyl isocyanates with 3-amino-1-arylimino-1H-isoindoles in the presence of triethylamine. In some events alongside the main product isomeric 2-trifluoromethyl-2,3-dihydro-1,3,5-triazino[2,1-a]isoindol-4-ones were obtained. The regioselectivity of the reaction is affected by sterical and electronic characteristics of substituents and by temperature.
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页码：263 / 270
页数：7
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