Involvement of cAMP in neuronal survival and axonal regeneration

被引：37

作者：

Cui Q. ^{[1
,3
]}

So K.-F. ^{[2
]}

机构：

[1] Laboratory for Neural Repair, Shantou University Medical College, Shantou 515031

[2] Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong

[3] School of Anatomy/Human Biology, Western Australia Inst. Med. Res., The University of Western Australia, Perth, WA

来源：

Anatomical Science International | 2004年 / 79卷 / 4期

基金：

英国医学研究理事会;

关键词：

Axonal regeneration; cAMP; Central nervous system; Neuronal survival;

D O I：

10.1111/j.1447-073x.2004.00089.x

中图分类号：

学科分类号：

摘要：

In vitro, cAMP elevation alters neuronal responsiveness to diffusible growth factors and overcomes myelin-associated inhibitory molecules. Significant advances have been made recently in understanding the role of increases in cAMP in promoting axonal growth. Importantly, it has now been shown that cAMP elevation can promote axonal regeneration and functional recovery after central nervous system injury. Elevation of cAMP can be achieved via either direct application of cAMP analogs or an inhibitor of the enzyme phosphodiesterase that degrades cAMP in vivo. Current information points to a number of protein kinase A-mediated pathways (mitogen-activated protein kinase/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/akt pathway activation and Rho inactivation) underlying cAMP elevation-induced neuronal survival and axonal regeneration.

引用

页码：209 / 212

页数：3

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