Developmental and tissue-specific expression of NITRs

被引：0
作者：
Jeffrey A. Yoder
Poem M. Turner
Phillip D. Wright
Valérie Wittamer
Julien Y. Bertrand
David Traver
Gary W. Litman
机构：
[1] College of Veterinary Medicine,Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research
[2] North Carolina State University,Division of Biological Sciences, Section of Cell and Developmental Biology, Department of Cellular and Molecular Medicine
[3] University of California,Department of Pediatrics
[4] San Diego,Department of Molecular Genetics
[5] University of South Florida College of Medicine,undefined
[6] USF/ACH Children’s Research Institute,undefined
[7] H. Lee Moffitt Cancer Center and Research Institute,undefined
[8] All Children’s Hospital,undefined
来源：
Immunogenetics | 2010年 / 62卷
关键词：
Innate immunity; Lymphocytes; Natural killer receptors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Novel immune-type receptors (NITRs) are encoded by large multi-gene families and share structural and signaling similarities to mammalian natural killer receptors (NKRs). NITRs have been identified in multiple bony fish species, including zebrafish, and may be restricted to this large taxonomic group. Thirty-nine NITR genes that can be classified into 14 families are encoded on zebrafish chromosomes 7 and 14. Herein, we demonstrate the expression of multiple NITR genes in the zebrafish ovary and during embryogenesis. All 14 families of zebrafish NITRs are expressed in hematopoietic kidney, spleen and intestine as are immunoglobulin and T cell antigen receptors. Furthermore, all 14 families of NITRs are shown to be expressed in the lymphocyte lineage, but not in the myeloid lineage, consistent with the hypothesis that NITRs function as NKRs. Sequence analyses of NITR amplicons identify known alleles and reveal additional alleles within the nitr1, nitr2, nitr3, and nitr5 families, reflecting the recent evolution of this gene family.
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页码：117 / 122
页数：5
相关论文
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