Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase

被引：0
作者：
Roni Nowarski
Elena Britan-Rosich
Tamar Shiloach
Moshe Kotler
机构：
[1] the Hebrew University-Hadassah Medical School,Department of Pathology and the Lautenberg Center for General and Tumor Immunology
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
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摘要：
APOBEC3G is a cytidine deaminase that can be incorporated into HIV-1 virions and process the viral genome upon cell infection, leading to viral hypermutation and inactivation. APOBEC3G's activities are counteracted by viral protein Vif. Using a sensitive enzymatic assay, low levels of APOBEC3G can be detected associated to Vif(+) virions. Furthermore, the authors show that APOBEC3G functions in a distributive manner and causes dispersed hypermutation via intersegmental transfer.
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页码：1059 / 1066
页数：7
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共 153 条
  • [1] Riggs AD(1970)The J. Mol. Biol. 53 401-417
  • [2] Bourgeois S(1981) repressor-operator interaction. 3. Kinetic studies Biochemistry 20 6929-6948
  • [3] Cohn M(1981)Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory Biochemistry 20 6961-6977
  • [4] Berg OG(1989)Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The J. Biol. Chem. 264 675-678
  • [5] Winter RB(1994) repressor–operator interaction: kinetic measurements and conclusions Science 263 769-770
  • [6] von Hippel PH(2000)Facilitated target location in biological systems EMBO J. 19 6546-6557
  • [7] Winter RB(1999)Protein-DNA recognition: new perspectives and underlying themes Science 284 958-961
  • [8] Berg OG(2000)One- and three-dimensional pathways for proteins to reach specific DNA sites Nature 408 873-876
  • [9] von Hippel PH(2001)Action of DNA repair endonuclease ERCC1/XPF in living cells Science 291 843-847
  • [10] von Hippel PH(2008)Rapid exchange of histone H1.1 on chromatin in living human cells Nat. Struct. Mol. Biol. 15 768-774
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