Inherited risk factors for venous thromboembolism

被引：0
作者：
Ida Martinelli
Valerio De Stefano
Pier M. Mannucci
机构：
[1] Angelo Bianchi Bonomi Hemophilia and Thrombosis Center,
[2] Fondazione IRCCS Ca' Granda,undefined
[3] Ospedale Maggiore Policlinico,undefined
[4] Institute of Hematology,undefined
[5] Catholic University,undefined
[6] Scientific Direction,undefined
[7] Fondazione IRCCS Ca' Granda,undefined
[8] Ospedale Maggiore Policlinico,undefined
来源：
Nature Reviews Cardiology | 2014年 / 11卷
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摘要：
Knowledge about the spectrum of genetic abnormalities causing thrombophilia has greatly expanded in the past 20 yearsThese abnormalities increase the risk of venous thromboembolism (VTE) by causing blood hypercoagulability through the impairment of natural anticoagulant pathways or the potentiation of procoagulantsVTE risk is higher in carriers of natural anticoagulant deficiencies, homozygous defects, and multiple abnormalities (severe thrombophilia) than in heterozygotes for factor V Leiden and prothrombin 20210A (mild thrombophilia)Family history of VTE is a strong risk factor for VTE regardless of the presence of known VTE susceptibility genesThrombophilia screening is useful in some instances to inform the optimum duration of secondary prophylaxis in patients who have developed VTE and are at high risk of recurrenceThrombosis-free individuals in risk-enhancing situations (pregnancy, oral contraceptive use, hormone replacement therapy, orthopaedic surgery) do not require thrombophilia screening, except in families with natural anticoagulant deficiencies or history of VTE
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页码：140 / 156
页数：16
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