Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

被引：0
|
作者：
Alexandre Bozec
Marius Ilie
Olivier Dassonville
Elodie Long
Gilles Poissonnet
José Santini
Emmanuel Chamorey
Marc Ettaiche
Damien Chauvière
Frédéric Peyrade
Christophe Hebert
Karen Benezery
Anne Sudaka
Juliette Haudebourg
Eric Selva
Paul Hofman
机构：
[1] Institut Universitaire de la Face et du Cou,Department of Surgery
[2] IRCAN Inserm U1081 Team 3,Faculty of Medicine
[3] Pasteur Hospital,Laboratory of Clinical and Experimental Pathology
[4] Pasteur Hospital,Human Biobank
[5] Antoine Lacassagne Centre,Department of Statistics
[6] Antoine Lacassagne Centre,Department of Medical Oncology
[7] Antoine Lacassagne Centre,Department of Radiotherapy
[8] Antoine Lacassagne Centre,Department of Pathology
来源：
European Archives of Oto-Rhino-Laryngology | 2013年 / 270卷
关键词：
Head and neck squamous cell carcinoma; Oral cavity; Oropharynx; Circulating tumor cells; CellSearch system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher’s exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.
引用
收藏
页码：2745 / 2749
页数：4
相关论文
共 50 条
  • [41] Circulating miRNA is a novel marker for head and neck squamous cell carcinoma
    Hsu, Cheng-Ming
    Lin, Pai-Mei
    Wang, Yu-Ming
    Chen, Zong-Jyun
    Lin, Sheng-Fung
    Yang, Ming-Yu
    TUMOR BIOLOGY, 2012, 33 (06) : 1933 - 1942
  • [42] Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma
    Qian, Xu
    Wagner, Steffen
    Ma, Chenming
    Coordes, Annekatrin
    Gekeler, Julia
    Klussmann, Jens P.
    Hummel, Michael
    Kaufmann, Andreas M.
    Albers, Andreas E.
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (07) : 1151 - 1158
  • [43] Neoadjuvant programmed cell death 1 blockade combined with chemotherapy for locally advanced head and neck squamous cell carcinoma
    Ping Han
    Faya Liang
    Pan Song
    Taowei Wu
    Yangyang Li
    Ming Gao
    Peiliang Lin
    Jianming Fan
    Xiaoming Huang
    Holistic Integrative Oncology, 3 (1):
  • [44] Prognostic significance of surgical extranodal extension in head and neck squamous cell carcinoma patients
    Matsumoto, Fumihiko
    Mori, Taisuke
    Matsumura, Satoko
    Matsumoto, Yoshifumi
    Fukasawa, Masahiko
    Teshima, Masanori
    Kobayashi, Kenya
    Yoshimoto, Seiichi
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 47 (08) : 699 - 704
  • [45] Understanding the tumor microenvironment in head and neck squamous cell carcinoma
    Rad, Habib Sadeghi
    Shiravand, Yavar
    Radfar, Payar
    Ladwa, Rahul
    Perry, Chris
    Han, Xiaoyuan
    Warkiani, Majid Ebrahimi
    Adams, Mark N.
    Hughes, Brett G. M.
    O'Byrne, Ken
    Kulasinghe, Arutha
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2022, 11 (06)
  • [46] Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma
    Xu Qian
    Steffen Wagner
    Chenming Ma
    Annekatrin Coordes
    Julia Gekeler
    Jens P. Klussmann
    Michael Hummel
    Andreas M. Kaufmann
    Andreas E. Albers
    Journal of Cancer Research and Clinical Oncology, 2014, 140 : 1151 - 1158
  • [47] Severe gastrointestinal bleeding in patients with locally advanced head and neck squamous cell carcinoma treated by concurrent radiotherapy and Cetuximab
    Naoya Murakami
    Seiichi Yoshimoto
    Fumihiko Matsumoto
    Takao Ueno
    Yoshinori Ito
    Satoru Watanabe
    Kazuma Kobayashi
    Ken Harada
    Mayuka Kitaguchi
    Shuhei Sekii
    Kana Takahashi
    Kotaro Yoshio
    Koji Inaba
    Madoka Morota
    Minako Sumi
    Yutaka Saito
    Jun Itami
    Journal of Cancer Research and Clinical Oncology, 2015, 141 : 177 - 184
  • [48] Cetuximab-Containing Combinations in Locally Advanced and Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
    Taberna, Miren
    Oliva, Marc
    Mesia, Ricard
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [49] A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
    Patel, Shetal A.
    Gibson, Michael K.
    Deal, Allison
    Sheth, Siddharth
    Heiling, Hilary
    Johnson, Steven M.
    Douglas, Kathe
    Flores, Melissa
    Blumberg, Jeffrey
    Lumley, Catherine
    Yarbrough, Wendell G.
    Shen, Colette
    Chera, Bhishamjit S.
    Bauman, Jessica R.
    Hackman, Trevor
    Weiss, Jared
    CANCER, 2023, 129 (21) : 3381 - 3389
  • [50] Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma
    Lee, Nicholas C. J.
    Kelly, Jacqueline R.
    An, Yi
    Park, Henry S.
    Judson, Benjamin L.
    Burtness, Barbara A.
    Husain, Zain A.
    CANCER, 2019, 125 (12) : 2018 - 2026
12345