Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

被引：0
|
作者：
Alexandre Bozec
Marius Ilie
Olivier Dassonville
Elodie Long
Gilles Poissonnet
José Santini
Emmanuel Chamorey
Marc Ettaiche
Damien Chauvière
Frédéric Peyrade
Christophe Hebert
Karen Benezery
Anne Sudaka
Juliette Haudebourg
Eric Selva
Paul Hofman
机构：
[1] Institut Universitaire de la Face et du Cou,Department of Surgery
[2] IRCAN Inserm U1081 Team 3,Faculty of Medicine
[3] Pasteur Hospital,Laboratory of Clinical and Experimental Pathology
[4] Pasteur Hospital,Human Biobank
[5] Antoine Lacassagne Centre,Department of Statistics
[6] Antoine Lacassagne Centre,Department of Medical Oncology
[7] Antoine Lacassagne Centre,Department of Radiotherapy
[8] Antoine Lacassagne Centre,Department of Pathology
来源：
European Archives of Oto-Rhino-Laryngology | 2013年 / 270卷
关键词：
Head and neck squamous cell carcinoma; Oral cavity; Oropharynx; Circulating tumor cells; CellSearch system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher’s exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.
引用
收藏
页码：2745 / 2749
页数：4
相关论文
共 50 条
  • [1] Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma
    Bozec, Alexandre
    Ilie, Marius
    Dassonville, Olivier
    Long, Elodie
    Poissonnet, Gilles
    Santini, Jose
    Chamorey, Emmanuel
    Ettaiche, Marc
    Chauviere, Damien
    Peyrade, Frederic
    Hebert, Christophe
    Benezery, Karen
    Sudaka, Anne
    Haudebourg, Juliette
    Selva, Eric
    Hofman, Paul
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2013, 270 (10) : 2745 - 2749
  • [2] Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma
    Liu, Kun
    Chen, Nanxiang
    Wei, Jian
    Ma, Lin
    Yang, Shiming
    Zhang, Xinxin
    ONCOLOGY REPORTS, 2020, 43 (05) : 1525 - 1535
  • [3] Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck
    Harris, Ethan J.
    Huang, Julian
    Carroll, Erin
    Lowe, Alarice C.
    Chau, Nicole G.
    Rabinowits, Guilherme
    Haddad, Robert
    Hanna, Glenn J.
    Haddad, Tyler
    Sanborn, Matthew
    Kacew, Alec
    Lorch, Jochen
    LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 2020, 5 (06): : 1063 - 1069
  • [4] Evaluation of therapeutic efficacy with CytoSorter® circulating tumor cell-capture system in patients with locally advanced head and neck squamous cell carcinoma
    Zheng, Weihui
    Zhang, Yibiao
    Guo, Liang
    Wang, Shengye
    Fang, Meiyu
    Mao, Weimin
    Lou, Jianlin
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 5857 - 5869
  • [5] Prognostic value of circulating tumor cells with podoplanin expression in patients with locally advanced or metastatic head and neck squamous cell carcinoma
    Hsieh, Jason Chia-Hsun
    Lin, Hung-Chih
    Huang, Chi-Ya
    Hsu, Hsung-Ling
    Wu, Tyler Min-Hsien
    Lee, Chia-Lin
    Chen, Min-Chi
    Wang, Hung-Ming
    Tseng, Ching-Ping
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (10): : 1448 - 1455
  • [6] Circulating tumor cells in patients with head and neck squamous cell carcinoma: Feasibility of detection and quantitation
    Kawada, Tomoyuki
    Takahashi, Hideyuki
    Sakakura, Koichi
    Ida, Shota
    Mito, Ikko
    Toyoda, Minoru
    Chikamatsu, Kazuaki
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2017, 39 (11): : 2180 - 2186
  • [7] Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck
    Tinhofer, I.
    Konschak, R.
    Stromberger, C.
    Raguse, J. -D.
    Dreyer, J. H.
    Joehrens, K.
    Keilholz, U.
    Budach, V.
    ANNALS OF ONCOLOGY, 2014, 25 (10) : 2042 - 2047
  • [8] Circulating Tumor Cells Correlate With Prognosis in Head and Neck Squamous Cell Carcinoma
    Zhou, Shichao
    Wang, Lili
    Zhang, Wenying
    Liu, Feng
    Zhang, Yanjie
    Jiang, Bin
    Wang, JiongYi
    Yuan, Haihua
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2021, 20
  • [9] Challenges in circulating tumor cell detection by the CellSearch system
    Andree, Kiki C.
    van Dalum, Guus
    Terstappen, Leon W. M. M.
    MOLECULAR ONCOLOGY, 2016, 10 (03) : 395 - 407
  • [10] Prognostic significance of PD-L1 expression on circulating tumor cells in patients with head and neck squamous cell carcinoma
    Strati, A.
    Koutsodontis, G.
    Papaxoinis, G.
    Angelidis, I.
    Zavridou, M.
    Economopoulou, P.
    Kotsantis, I.
    Avgeris, M.
    Mazel, M.
    Perisanidis, C.
    Sasaki, C.
    Alix-Panabieres, C.
    Lianidou, E.
    Psyrri, A.
    ANNALS OF ONCOLOGY, 2017, 28 (08) : 1923 - 1933
12345