Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1α

被引:0
作者
M. M. Schilling
J. K. Oeser
J. K. Chandy
B. P. Flemming
S. R. Allen
R. M. O’Brien
机构
[1] Vanderbilt University Medical School,Department of Molecular Physiology and Biophysics
来源
Diabetologia | 2008年 / 51卷
关键词
Diabetes; Glucose-6-phosphatase; HNF-4alpha; PGC-1alpha; Promoter; Transcription;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1505 / 1514
页数:9
相关论文
共 166 条
[1]  
Van Schaftingen E(2002)The glucose-6-phosphatase system Biochem J 362 513-532
[2]  
Gerin I(2002)Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex Curr Mol Med 2 121-143
[3]  
Chou JY(1993)Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin J Biol Chem 268 25019-25025
[4]  
Matern D(1994)13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus J Clin Invest 94 2369-2376
[5]  
Mansfield BC(2005)Metabolic control through the PGC-1 family of transcription coactivators Cell Metab 1 361-370
[6]  
Chen YT(2006)PGC-1 coactivators: inducible regulators of energy metabolism in health and disease J Clin Invest 116 615-622
[7]  
Barzilai N(2001)Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 Nature 413 131-138
[8]  
Rossetti L(2004)Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice Cell 119 121-135
[9]  
Cline GW(2005)PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis PLoS Biol 3 e101-19008
[10]  
Rothman DL(2006)Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice J Biol Chem 281 19000-515