Melatonin in children with autistic spectrum disorders: recent and practical data

被引：0
作者：
C. Doyen
D. Mighiu
K. Kaye
C. Colineaux
C. Beaumanoir
Y. Mouraeff
C. Rieu
P. Paubel
Y. Contejean
机构：
[1] Sainte Anne Hospital,Department of Child and Adolescent Psychopathology
[2] Sainte Anne Hospital,Department of Pharmacy and Sterilization
来源：
European Child & Adolescent Psychiatry | 2011年 / 20卷
关键词：
Melatonin; Autism; Childhood; Sleep; Disorders;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Over the last 20 years, melatonin, a pineal hormone synthesized from serotonin, has been implicated in various studies on the autism spectrum disorder (ASD) and altered melatonin levels were detected in subgroups of subjects with ASD. Its effect on sleep disturbances got the attention of clinicians and several investigations were carried out to determine the usefulness and safety of melatonin administration in this disorder. Hypotheses were also raised regarding the possibility that the dysfunctional synthesis and secretion of melatonin detected in subgroups of subjects with ASD may increase the risk as well the severity of ASD. The purpose of this paper is to review our pharmacokinetic knowledge on melatonin and present results from recent studies on sleep disorders in autism, their treatment with melatonin and the impact of melatonin prescription in children with ASD evaluated in a Diagnostic Center for Autism Spectrum Disorder in Paris, France.
引用
收藏
页码：231 / 239
页数：8
相关论文
共 120 条
[1]  
Aman MG(2003)Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio J Autism Dev Disord 33 527-534
[2]  
Lam KS(2008)Melatonin for insomnia in children with autism spectrum disorders J Child Neurol 23 482-485
[3]  
Collier-Crespin A(2007)The possible interplay of synaptic and clock genes in autism spectrum disorders Cold Spring Harb Symp Quant Biol 72 645-654
[4]  
Andersen IM(1990)A novel biochemical model linking dysfunction in brain melatonin, proopiomelanocortin peptides, and serotonin in autism Biol Psychiatry 28 773-793
[5]  
Kaczmarska J(2006)Sleep problems and information processing, a “disconnection effect” in autism? Med Hypotheses 66 1245-1246
[6]  
McGrew SG(2009)Melatonin in treatment of chronic sleep disorders in adults with autism: a retrospective study Swiss Med Wkly 139 293-296
[7]  
Malow BA(2006)Randomized controlled trial of melatonin for the children with autistic spectrum disorders Child Care Health Dev 32 585-589
[8]  
Bourgeron T(2006)An open-label study of controlled release melatonin in treatment of sleep disorders in children with autism J Autism Dev Disord 36 741-752
[9]  
Chamberlain RS(2009)Complementary alternative medicine for children with autism: a physician survey J Autism Dev Disord 39 996-1005
[10]  
Herman BH(2005)Melatonin: un panacea for desperate parents? (Hype or truth) Arch Dis Child 90 986-987
12345678910