The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes

被引：1
作者：
Shanna Hamilton
Roland Veress
Andriy Belevych
Dmitry Terentyev
机构：
[1] The Ohio State University,Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Wexner Medical Center
来源：
Pflügers Archiv - European Journal of Physiology | 2021年 / 473卷
关键词：
Calcium-dependent arrhythmia; Calcium homeostasis remodeling; Heart failure; Catecholaminergic polymorphic ventricular tachycardia; Long QT syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sudden cardiac death due to malignant ventricular arrhythmias remains the major cause of mortality in the postindustrial world. Defective intracellular Ca2+ homeostasis has been well established as a key contributing factor to the enhanced propensity for arrhythmia in acquired cardiac disease, such as heart failure or diabetic cardiomyopathy. More recent advances provide a strong basis to the emerging view that hereditary cardiac arrhythmia syndromes are accompanied by maladaptive remodeling of Ca2+ homeostasis which substantially increases arrhythmic risk. This brief review will focus on functional changes in elements of Ca2+ handling machinery in cardiomyocytes that occur secondary to genetic mutations associated with catecholaminergic polymorphic ventricular tachycardia, and long QT syndrome.
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页码：377 / 387
页数：10
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