Hepatic enzyme induction and acute endocrine effects of 2,2′,3,3′,4,6′-hexachlorobiphenyl and 2,2′,3,4′,5′,6-hexachlorobiphenyl in prepubertal female rats

被引：8
作者：
Li M.-H. [1 ]
Hsu P.-C. [2 ]
Guo Y.L. [3 ]
机构：
[1] Department of Geography, National Taiwan University, Taipei 106, Roosevelt Road
[2] Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Yuanchau, Kaohsiung
[3] Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan 70428
来源：
Archives of Environmental Contamination and Toxicology | 2001年 / 41卷 / 3期
关键词：
Thyroid Hormone; PCBs; Biphenyl; Thyroxine; Enzyme Induction;
D O I：
10.1007/s002440010263
中图分类号：
学科分类号：
摘要：
Polychlorinated biphenyls (PCBs) with the liable 2,3,6-substitution are important components of certain commercial mixtures and frequently detected in biota, but little is known about their enzyme induction abilities and possible endocrine-disrupting effects. CB 132 (2,2′,3,3′,4,6′-hexachlorophenyl) and CB 149 (2,2′3,4′,5′,6-hexachlorophenyl) were investigated in weanling female rats dosed intraperitoneally on days 21 and 22 and killed on day 24 of age. Uterotropic response, serum thyroid hormone, and hepatic enzyme induction were examined in prepubertal female rats treated with these two environmentally relevant 2,3,6-substituted chlorobiphenyl (CB) congeners from 8 mg/kg to 96 mg/kg. The readily metabolized CB 132 did not cause any significant increase in all endpoints measured in the present study. On the other hand, CB 149 was a weak PROD and BROD inducer and a modest depleter of serum thyroxine in prepubertal female rats. The finding of thyroid hormone disruption by CB 149 may lead to biologically significant neurobehavioral and neurochemical changes in developing animals via milk lactation.
引用
收藏
页码：381 / 385
页数：4
相关论文
共 30 条
  • [1] Blanch G.P., Glausch A., Schuring V., Determination of the enantiomeric ratios of chiral PCB 95 and 149 in human milk samples by multidimensional gas chromatography with ECD and MN (SIM) detection, Eur Food Res Technol, 209, pp. 294-296, (1999)
  • [2] Byrne J.J., Carbone J.P., Hanson E.A., Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl, Endocrinology, 121, pp. 520-527, (1987)
  • [3] Collins W.T., Capen C.C., Ultrastructural and functional alterations of the rat thyroid gland produced by polychlorinated biphenyls compared with iodide excess and deficiency, and thyrotropin and thyroxine administration, Virchows Arch B Cell Path, 33, pp. 213-231, (1980)
  • [4] Denomme M.A., Bandiera S., Lambert I., Copp L., Safe L., Safe S., Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes, Biochem Pharmacol, 32, pp. 2955-2963, (1983)
  • [5] Dussault J.H., Ruel J., Thyroid hormones and brain development, Ann Rev Physiol, 49, pp. 321-334, (1987)
  • [6] Frame G.M., Cochran J.W., Bowadt S.S., Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC systems optimized for comprehensive, quantitative, congener-specific analysis, J High Resol Chromatogr, 19, pp. 657-668, (1996)
  • [7] Glausch A., Hahn J., Schurig V., Enantioselective determination of chiral 2,2′,3,3′4,6′-hexachlorobiphenyl (PCB 132) in human milk samples by multidimensional gas chromatography/electron capture detection and by mass spectrometry, Chemosphere, 30, pp. 2079-2085, (1995)
  • [8] Glausch A., Blanch G.P., Schurig V., Enantioselective analysis of chiral polychlorinated biphenyls in sediment samples by multidimensional gas chromatography-electro-capture detection after steam distillation-solvent extract and sulfur removal, J Chromatogr A, 723, pp. 399-404, (1996)
  • [9] Guengerich F.P., Microsomal enzymes involved in toxicology-analysis and separation, pp. 609-634, (1982)
  • [10] Hansen L.G., Stepping backward to improve assessment of PCB congener toxicities, Environ Health Perspect, 106 S, pp. 171-189, (1998)
123