Acute kidney injury and COVID-19: lung-kidney crosstalk during severe inflammation

被引：8

作者：

Mayerhoefer, Timo ^{[1
]}

Perschinka, Fabian ^{[1
]}

Joannidis, Michael ^{[1
]}

机构：

[1] Med Univ Innsbruck, Gemeinsame Einrichtung Internist Intens & Notfall, Innere Med, Anichstr 35, A-6020 Innsbruck, Austria

来源：

MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN | 2022年 / 117卷 / 05期

关键词：

SARS-CoV-2; Inflammation; Sepsis; Respiratory distress syndrome; Artificial respiration; CRITICALLY-ILL PATIENTS; HOSPITALIZED-PATIENTS; REPLACEMENT THERAPY; CRITICAL ILLNESS; DISEASE; AKI; EPIDEMIOLOGY; PREVALENCE; GUIDELINES; MANAGEMENT;

D O I：

10.1007/s00063-022-00919-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) is common in critically ill patients. Renal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) appears to play only a minor role, whereas the pathological inflammatory response associated with severe COVID-19 is highly relevant. Both the consequences of invasive ventilation and acute respiratory distress syndrome (ARDS) caused by COVID-19 have a significant impact on the pathogenesis of AKI. High ventilation pressures compromise renal perfusion and, thus, may contribute to the development of AKI. The inflammatory response caused by ARDS, as well as the endothelial dysfunction typical of COVID-19 in combination with hypercoagulability are further factors that affect the kidney.

引用

页码：342 / 348

页数：7

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