Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes

被引：0
作者：
Terry W Hermiston
Irene Kuhn
机构：
[1] Berlex Biosciences,
来源：
Cancer Gene Therapy | 2002年 / 9卷
关键词：
oncolytic virus; armed therapeutic virus; gene therapy; cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oncolytic viruses are attractive therapeutics for cancer because they selectively amplify, through replication and spread, the input dose of virus in the target tumor. To date, clinical trials have demonstrated marked safety but have not realized their theoretical efficacy potential. In this review, we consider the potential of armed therapeutic viruses, whose lytic potential is enhanced by genetically engineered therapeutic transgene expression from the virus, as potential vehicles to increase the potency of these agents. Several classes of therapeutic genes are outlined, and potential synergies and hurdles to their delivery from replicating viruses are discussed.
引用
收藏
页码：1022 / 1035
页数：13
相关论文
共 50 条
[41]   Immunoglobulin-like transcript 2 (ILT2) is a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses [J].
Zloza, Andrew ;
Kim, Dae Won ;
Kim-Schulze, Seunghee ;
Jagodal, Michael C. ;
Monsurro, Vladia ;
Marincola, Francesco M. ;
Kaufman, Howard L. .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2014, 2
[42]   Fueling immune checkpoint blockade with oncolytic viruses: Current paradigms and challenges ahead [J].
Li, Shu-Jin ;
Sun, Zhi-Jun .
CANCER LETTERS, 2022, 550
[43]   Turing Bifurcation Induced by Cross-Diffusion and Amplitude Equation in Oncolytic Therapeutic Model: Viruses as Anti-Tumor Means [J].
Najm, Fatiha ;
Yafia, Radouane ;
Alaoui, M. A. Aziz .
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2023, 33 (05)
[44]   Molecular strategies for the treatment of malignant glioma—genes, viruses, and vaccines [J].
Lee A. Selznick ;
Mohammed F. Shamji ;
Peter Fecci ;
Matthias Gromeier ;
Allan H. Friedman ;
John Sampson .
Neurosurgical Review, 2008, 31 :141-155
[45]   Molecular strategies for the treatment of malignant glioma - genes, viruses, and vaccines [J].
Selznick, Lee A. ;
Shamji, Mohammed F. ;
Fecci, Peter ;
Gromeier, Matthias ;
Friedman, Allan H. ;
Sampson, John .
NEUROSURGICAL REVIEW, 2008, 31 (02) :141-155
[46]   The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses [J].
Pelin, Adrian ;
Wang, Jiahu ;
Bell, John ;
Le Boeuf, Fabrice .
ONCOLYTIC VIROTHERAPY, 2018, 7 :25-35
[47]   Arming HSV-Based Oncolytic Viruses with the Ability to Redirect the Host's Innate Antiviral Immunity to Attack Tumor Cells [J].
Fu, Xinping ;
Tao, Lihua ;
Wu, Wanfu ;
Zhang, Xiaoliu .
MOLECULAR THERAPY-ONCOLYTICS, 2020, 19 :33-46
[48]   Viral warfare! Front-line defence and arming the immune system against cancer using oncolytic vaccinia and other viruses [J].
Dave, R. V. ;
Jebar, A. H. S. ;
Jennings, V. A. ;
Adair, R. A. ;
West, E. J. ;
Errington-Mais, F. ;
Toogood, G. J. ;
Melcher, A. A. .
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2014, 12 (04) :210-220
[49]   Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer [J].
Kirn, David H. ;
Thorne, Steve H. .
NATURE REVIEWS CANCER, 2009, 9 (01) :64-71
[50]   Combination of IAP Antagonists and INF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression [J].
Beug, Shawn T. ;
Pichette, Stephanie J. ;
St-Jean, Martine ;
Holbrook, Janelle ;
Walker, Danielle E. ;
LaCasse, Eric C. ;
Korneluk, Robert G. .
MOLECULAR THERAPY-ONCOLYTICS, 2018, 10 :28-39
12345