Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

被引：0
|
作者：
Gong Zhang
Magdalena Hubalewska
Zoya Ignatova
机构：
[1] Max-Planck-Institute of Biochemistry,Department of Cellular Biochemistry
[2] Institute of Biochemistry and Biology,Department of Biochemistry
[3] University of Potsdam,undefined
来源：
Nature Structural & Molecular Biology | 2009年 / 16卷
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摘要：
Rare codons along transcripts have been proposed to influence the local rate of translation and the folding of nascent polypeptide chains. Now this idea is demonstrated for a bacterial protein: rare-codon clusters are shown to affect translation rates, and this was important for efficient protein folding in vitro and in vivo.
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页码：274 / 280
页数：6
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