Direct and Indirect Electro-Oxidative Intramolecular C–H Aminations

The ubiquity of N-heterocycles in marketed drugs makes the development of metal-free methodologies for constructing C–N bonds of considerable importance. As an environmentally friendly method, electro-oxidative intramolecular C–H amination has emerged as a powerful platform for synthesizing nitrogen-containing heterocycles under metal- and external oxidant-free conditions. In this minireview, the main achievements in this direction since 2020 are summarized, with an emphasis on the substrate scope and mechanistic aspects. The reactions are classified into two categories: direct and indirect electro-oxidative intramolecular C–H aminations.